| The usefulness of 99mTc sulfur colloid bone marrow scintigraphy combined with 111In leucocyte scintigraphy in prosthetic joint infection. | |
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MedLine Citation:
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PMID: 15154708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess the extent to which bone marrow scintigraphy (BMS) makes the interpretation of leucocyte scintigraphy (LS) easier and improves its diagnostic value. METHODS: Seventy-three 111In LSs, 99mTc hydroxymethylene diphosphonate bone scintigraphies (BSs) and 99mTc sulfur colloid BMSs were performed in 60 patients with suspected infection related to a hip prosthesis or knee prosthesis, either in situ (+group, n = 43) or after removal for septic loosening (-group, n = 30). Bacteriological samples were obtained from all patients. LS was interpreted together with BS (LS-BS) or with BMS (LS-BMS) by three independent readers. RESULTS: The concordance among readers, estimated by the kappa test, was average with LS-BS (kappa/kappam coefficients = 0.58, 0.58 and 0.46, respectively, for the three pairs of readers) and excellent with LS-BMS (kappa/kappam coefficients = 1.00 for the three pairs of readers). With LS-BS, 64/219 interpretations were equivocal whereas only one was equivocal with LS-BMS. Sensitivity, specificity and accuracy of LS-BMS were, respectively, 80%, 94% and 91% in the +group, and 33%, 100% and 93% in the -group. CONCLUSION: We conclude that (1) the interpretation of the results for LS-BMS is very easy, in contrast to LS-BS; (2) the diagnostic value of LS-BMS for detecting infected joint prostheses is good; and (3) additional data are needed to assess the accuracy of LS-BMS when the prosthesis has been removed. |
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Authors:
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Isabelle El Espera; Cyrille Blondet; Véronique Moullart; Lazhar Saïdi; Eric Havet; Patrice Mertl; Brigitte Canarelli; Jean-Luc Schmit; Marc-Etienne Meyer |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 25 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-05-24 Completed Date: 2004-11-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 171-5 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, University Hospital, Amiens, France. elesper.isabelle@chu-amiens.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Marrow / radionuclide imaging* Hip Prosthesis Humans Image Interpretation, Computer-Assisted Indium Radioisotopes / diagnostic use Joint Prosthesis* Knee Prosthesis Leukocytes / radionuclide imaging* Prosthesis-Related Infections / radionuclide imaging* Radiopharmaceuticals / diagnostic use* Technetium Tc 99m Sulfur Colloid / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Indium Radioisotopes; 0/Radiopharmaceuticals; 0/Technetium Tc 99m Sulfur Colloid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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