Document Detail

The usefulness of 99mTc sulfur colloid bone marrow scintigraphy combined with 111In leucocyte scintigraphy in prosthetic joint infection.
MedLine Citation:
PMID:  15154708     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the extent to which bone marrow scintigraphy (BMS) makes the interpretation of leucocyte scintigraphy (LS) easier and improves its diagnostic value. METHODS: Seventy-three 111In LSs, 99mTc hydroxymethylene diphosphonate bone scintigraphies (BSs) and 99mTc sulfur colloid BMSs were performed in 60 patients with suspected infection related to a hip prosthesis or knee prosthesis, either in situ (+group, n = 43) or after removal for septic loosening (-group, n = 30). Bacteriological samples were obtained from all patients. LS was interpreted together with BS (LS-BS) or with BMS (LS-BMS) by three independent readers. RESULTS: The concordance among readers, estimated by the kappa test, was average with LS-BS (kappa/kappam coefficients = 0.58, 0.58 and 0.46, respectively, for the three pairs of readers) and excellent with LS-BMS (kappa/kappam coefficients = 1.00 for the three pairs of readers). With LS-BS, 64/219 interpretations were equivocal whereas only one was equivocal with LS-BMS. Sensitivity, specificity and accuracy of LS-BMS were, respectively, 80%, 94% and 91% in the +group, and 33%, 100% and 93% in the -group. CONCLUSION: We conclude that (1) the interpretation of the results for LS-BMS is very easy, in contrast to LS-BS; (2) the diagnostic value of LS-BMS for detecting infected joint prostheses is good; and (3) additional data are needed to assess the accuracy of LS-BMS when the prosthesis has been removed.
Isabelle El Espera; Cyrille Blondet; Véronique Moullart; Lazhar Saïdi; Eric Havet; Patrice Mertl; Brigitte Canarelli; Jean-Luc Schmit; Marc-Etienne Meyer
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  25     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-05-24     Completed Date:  2004-11-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Department of Nuclear Medicine, University Hospital, Amiens, France.
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MeSH Terms
Bone Marrow / radionuclide imaging*
Hip Prosthesis
Image Interpretation, Computer-Assisted
Indium Radioisotopes / diagnostic use
Joint Prosthesis*
Knee Prosthesis
Leukocytes / radionuclide imaging*
Prosthesis-Related Infections / radionuclide imaging*
Radiopharmaceuticals / diagnostic use*
Technetium Tc 99m Sulfur Colloid / diagnostic use*
Reg. No./Substance:
0/Indium Radioisotopes; 0/Radiopharmaceuticals; 0/Technetium Tc 99m Sulfur Colloid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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