Document Detail

The use of vaginal misoprostol for second-trimester pregnancy termination in women with previous single cesarean section.
MedLine Citation:
PMID:  16982234     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: This retrospective study reports of 85 women in the second trimester with one prior cesarean section undergoing medical abortion of a viable unwanted pregnancy using vaginal misoprostol. Two regimens that were selected in a nonrandomized manner were used. MATERIALS AND METHODS: Eighty-five women treated with vaginal misoprostol in a 3-year period were retrospectively analyzed. All received 400 mug of misoprostol initially and 22 (25.8%) aborted. Then Group A (n=43) received subsequent administration of 200 microg every 6 h, whereas Group B (n=20) received 400 microg/6 h. RESULTS: All patients aborted. The groups had no statistical difference in mean age, gravidity, parity, gestational age, and time from previous cesarean section, and there was no difference in occurrence of side effects and mean induction to abortion time interval. The lower dosage group received a median of 600 microg of vaginal misoprostol (min 600 microg to max 1000 microg). There were no uterine ruptures, need for hysterotomy, or excess bleeding in any patient. CONCLUSIONS: This is the largest series reported to date of second-trimester pregnancy termination in cases with one previous cesarean section using only vaginal misoprostol. The study shows that both used regimens are safe and equally effective. All 85 women aborted.
Alexandros Daponte; Guy Nzewenga; Konstantinos D Dimopoulos; Franco Guidozzi
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2006-05-12
Journal Detail:
Title:  Contraception     Volume:  74     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-19     Completed Date:  2007-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  324-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University Hospital of Larissa, University of Thessalia, Larissa 41110, Greece.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage
Abortion, Induced / methods*
Administration, Intravaginal
Cesarean Section*
Dose-Response Relationship, Drug
Gestational Age
Misoprostol / administration & dosage*
Pregnancy Trimester, Second / drug effects*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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