Document Detail


The use of urokinase in acute myocardial infarction: report of two cases.
MedLine Citation:
PMID:  1151039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the course of a study (now including 53 patients) on the effectiveness of urokinase in the treatment of acute coronary occlusion, coronary angiography was performed in 2 patients before and after the use of this drug. In both instances the angiograms demonstrated obstruction in the coronary-artery branches, with additional narrowing and some collateral circulation. After urokinase therapy, blood flow was restored in the areas previously obstructed. These 2 case reports are presented because they demonstrate this favorable change in coronary blood flow in association with this particular form of therapy. It is hoped that the completed urokinase study may add some information concerning the effect of thrombolysis in the management of myocardial infarction.
Authors:
M S Mazel; F Parsa; R Riera
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  23     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-10-30     Completed Date:  1975-10-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  419-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Angiocardiography
Aspartate Aminotransferases / blood
Blood Coagulation Tests
Cineangiography
Collateral Circulation / drug effects
Coronary Angiography
Coronary Circulation / drug effects
Creatine Kinase / blood
Electrocardiography
Endopeptidases / therapeutic use*
Humans
L-Lactate Dehydrogenase / blood
Male
Middle Aged
Myocardial Infarction / drug therapy*,  enzymology,  radiography
Urokinase-Type Plasminogen Activator / administration & dosage,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.7.3.2/Creatine Kinase; EC 3.4.-/Endopeptidases; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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