Document Detail


The use of two multitests fx5 and fx10 in the diagnosis of food allergy in children: regarding 42 cases.
MedLine Citation:
PMID:  7702736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The multitests Cap RAST fx5 and fx10 (Pharmacia, Cap System) are used for a rapid biological diagnosis of food allergy. These tests were assessed in 29 children who presented 42 food allergies (FA) documented by prick tests, specific IgE and labial or oral provocation tests (single blind placebo controlled food challenges). When the multitests were positive, the search for specific IgE to the corresponding allergens was performed (Cap RAST, Pharmacia). The theoretical coverage of FA could be estimated according to the frequency of food allergens involved in the children. It reaches 85% for Cap RAST fx5 and 29% for Cap RAST fx10. The sensitivity of Cap RAST fx5 is 89% and 50% for Cap RAST fx10. Even in the case when the child had a single food allergy, the detail of specific IgE showed multiple positivities to several allergens included in the multitest. Consequently, the positive predictive value of Cap RAST was only 32%. Prick tests to the same allergens were more rarely positive, gaining thus a better positive predictive value. The authors propose the use of Cap RAST fx5, eventually completed by a Cap RAST to beef for the first approach of food allergy in children. They stress the point that prick tests have to be carried on subsequently, in order to select properly allergens responsible for food allergy.
Authors:
D A Moneret-Vautrin; S Frémont; G Kanny; G Déjardin; R Hatahet; J P Nicolas
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Allergie et immunologie     Volume:  27     ISSN:  0397-9148     ISO Abbreviation:  Allerg Immunol (Paris)     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-05     Completed Date:  1995-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245775     Medline TA:  Allerg Immunol (Paris)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  2-6     Citation Subset:  IM    
Affiliation:
Service de Médecine D, Centre Hospitalier Universitaire de Nancy, Hôpital de Brabois, Vandoeuvre, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Allergens / diagnostic use
Animals
Arachis hypogaea / adverse effects
Cattle
Child
Child, Preschool
Egg Proteins / adverse effects
Female
Food Hypersensitivity / diagnosis*
Humans
Immunoglobulin E / blood,  immunology
Infant
Intradermal Tests
Male
Meat / adverse effects
Milk Hypersensitivity / diagnosis
Predictive Value of Tests
Radioallergosorbent Test*
Reagent Kits, Diagnostic*
Sensitivity and Specificity
Single-Blind Method
Chemical
Reg. No./Substance:
0/Allergens; 0/Egg Proteins; 0/Reagent Kits, Diagnostic; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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