| The use of tumour volumetrics to assess response to therapy in anti-cancer clinical trials. | |
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MedLine Citation:
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PMID: 22242836 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Serial evaluations of tumour burden using imaging, mainly computed tomography and magnetic resonance imaging, form the basis for assessing treatment response in many clinical trials of anti-cancer therapeutics. Traditionally, these evaluations have been based on linear measurements of tumour size. Such measurements have limitations related to variability in technical factors, tumour morphology, and reader decisions. Measurements of entire tumour volumes may overcome some of the limitations of linear tumour measurements, improving our ability to reliably detect small changes, and increasing statistical power per subject in a trial. Certain technical factors are known to affect the accuracy and precision of volume measurements, and work is in progress to more thoroughly define these factors and to qualify tumour volume as a biomarker for the purposes of drug development. © 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society. |
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Authors:
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Gregory V Goldmacher; James Conklin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: - ISSN: 1365-2125 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society. |
Affiliation:
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Associate Director, Medical and Scientific Affairs, ICON Medical Imaging, 2800 Kelly Rd. Suite 200, Warrington, PA 18976, USA Senior Vice President, Medical and Scientific Affairs, ICON Medical Imaging, 2800 Kelly Rd. Suite 200, Warrington, PA 18976, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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