Document Detail


The use of transdermal clonidine in the hypertensive patient with chronic renal failure.
MedLine Citation:
PMID:  8428406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of transdermally administered clonidine was evaluated in twenty-four patients with mild-to-moderate hypertension (seated diastolic blood pressure 95-115 mmHg) and renal impairment. Patients were initially treated with oral clonidine; the dose was titrated until the seated diastolic pressure fell below 90 mmHg or a minimum 10% reduction in baseline was achieved. Oral clonidine produced a significant decrease in both systolic and diastolic blood pressure; mean seated diastolic blood pressure decreased 16.9 mmHg from baseline. When transdermal clonidine was substituted for twice daily dosage of oral clonidine, blood pressure decreases were fully maintained. Sixteen patients completed three months of stable-dose transdermal therapy. The results suggest that, in mild-to-moderate hypertensive patients with chronic renal impairment, blood pressure can be controlled with a once-weekly application of transdermal clonidine as effectively as with oral clonidine. Mean diastolic blood pressure was decreased approximately 17% during clonidine therapy independent of the severity of renal dysfunction or route of clonidine administration.
Authors:
D T Lowenthal; S D Saris; E Paran; N Cristal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nephrology     Volume:  39     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-05     Completed Date:  1993-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Affiliation:
Geriatric Research, Education and Clinical Center, VA Medical Center, University of Florida, Gainesville 32608-1197.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Administration, Oral
Adult
Aged
Blood Pressure / drug effects
Clonidine / administration & dosage*,  blood,  therapeutic use
Drug Administration Schedule
Female
Humans
Hypertension, Renal / drug therapy*
Kidney Failure, Chronic / complications*,  therapy
Male
Middle Aged
Renal Dialysis
Time Factors
Chemical
Reg. No./Substance:
4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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