Document Detail


The use of topical diphenylcyclopropenone for the treatment of extensive alopecia areata.
MedLine Citation:
PMID:  11148480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Highly variable results of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata have been reported so far. OBJECTIVE: The purposes of our study were to evaluate the efficacy and tolerability of DPCP in the treatment of chronic, extensive alopecia areata and to assess the long-term overall benefit of treatment. METHODS: Fifty-six patients with chronic, extensive alopecia areata were enrolled in an open-label clinical trial. After sensitization with 2% DPCP, progressively higher concentrations beginning at 0.001% were applied weekly for 6 to 12 months to one side of the scalp. RESULTS: Fifty-two of 56 patients completed therapy. Total regrowth of terminal hair was achieved in 25 of 52 patients (48%) at 6 months. The most frequent side effect was an eczematous reaction at the site of application. Notably, persistent response was observed in 60% of these patients after 6 to 18 months of follow-up (mean, 12 months). CONCLUSION: Topical DPCP treatment for alopecia areata is effective and well tolerated and provides prolonged therapeutic benefits.
Authors:
C Cotellessa; K Peris; E Caracciolo; C Mordenti; S Chimenti
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  44     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-09     Completed Date:  2001-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of L'Aquila, Italy. chimenti@univaq.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adolescent
Adult
Alopecia Areata / drug therapy*
Chronic Disease
Cyclopropanes / administration & dosage*,  adverse effects
Female
Humans
Male
Middle Aged
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cyclopropanes; 886-38-4/diphenylcyclopropenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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