Document Detail

The use of thrombomodulin to study epithelial cell differentiation in neoplastic and non-neoplastic oral lesions.
MedLine Citation:
PMID:  8600279     Owner:  NLM     Status:  MEDLINE    
Thrombomodulin (TM) is a glycoprotein originally isolated from rabbit lung vasculature and characterized as a natural endothelial anticoagulant. Thrombin binds to TM noncovalently with high affinity. Thrombin-TM complexes can activate protein C efficiently. Activated protein C inactivates factors Va and VIIIa and regulates the blood coagulation cascade. Thus TM converts thrombin from a procoagulant protease to an anticoagulant. TM is found on endothelial cells in veins, arteries and capillaries. Our previous study has shown that TM is also expressed on the cell surface of squamous epithelium. In the present study, we aimed to disclose differences in TM expression among normal, dysplastic, and malignant squamous epithelium in human oral mucosa by counting TM-positive cells in each lesion. TM was uniformly expressed in the spinous layer of normal human oral squamous epithelium. The number of TM-positive cells was not significantly different between normal epithelium, lichen planus and mild dysplasia. In contrast, in moderate and severe dysplasia and well-differentiated squamous cell carcinoma (SCC), there were significantly fewer positive cells compared with normal epithelium. In SCCs, the periphery and the central keratinized area of tumor islands were often negative. The proportion of TM-positive cells in poorly differentiated SCC was significantly lower than in well-differentiated SCC. These results indicate that TM may have diagnostic value in the histological examination of oral premalignant and malignant lesions.
M Tabata; S Yonezawa; K Sugihara; S Yamashita; I Maruyama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  24     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-05-01     Completed Date:  1996-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  443-9     Citation Subset:  D; IM    
First Department of Oral and Maxillofacial Surgery, Kagoshima University School of Medicine, Japan.
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MeSH Terms
Carcinoma, Squamous Cell / pathology
Cell Differentiation
Endothelium, Vascular / pathology
Epithelium / pathology
Gene Expression Regulation
Gene Expression Regulation, Neoplastic
Lichen Planus, Oral / pathology
Mouth Diseases / genetics,  pathology*
Mouth Mucosa / pathology*
Mouth Neoplasms / genetics,  pathology*
Precancerous Conditions / pathology
Thrombomodulin / analysis*,  genetics,  physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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