Document Detail

The use of thrombin in the radiology department.
MedLine Citation:
PMID:  18925399     Owner:  NLM     Status:  MEDLINE    
Thrombin is a naturally occurring coagulation protein that converts soluble fibrinogen into insoluble fibrin and plays a vital role in the coagulation cascade and in turn haemostasis. Thrombin also promotes platelet activation. In the last few years, there has been a rapid increase in the use of thrombin by radiologists in a variety of clinical circumstances. It is best known for its use in the treatment of pseudoaneurysms following angiography. However, there are now a variety of cases in the literature describing the treatment of traumatic, inflammatory and infected aneurysms with thrombin in a variety of locations within the human body. There have even been recent reports describing the use of thrombin in conventional aneurysms as well as ruptured aneurysms. Its use has also been described in the treatment of endoleaks (type II) following aneurysm repair. In nearly all of these cases, treatment with thrombin requires imaging guidance. Recently, thrombin has also been used as a topical treatment post-percutaneous intervention to reduce or stop bleeding. Most radiologists have only a limited knowledge of the pharmacodynamics of thrombin, its wide range of utilisation and its limitations. Apart from a few case reports and case series, there is little in the radiological literature encompassing the wide range of applications that thrombin may have in the radiology department. In this review article, we comprehensively describe the role and pathophysiology of thrombin, describing with examples many of its potential uses. Techniques of usage as well as pitfalls and limitations are also described.
E Ward; O Buckley; A Collins; R F Browne; W C Torreggiani
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-10-17
Journal Detail:
Title:  European radiology     Volume:  19     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-05     Completed Date:  2009-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  670-8     Citation Subset:  IM    
Department of Radiology, Adelaide and Meath Hospitals incorporating the National Children's Hospital, Tallaght, Dublin 24, Ireland.
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MeSH Terms
Aneurysm / drug therapy,  surgery
Aneurysm, False / drug therapy
Coagulants / therapeutic use
Hemorrhage / drug therapy
Radiology / methods*
Thrombin / therapeutic use*
Tomography, X-Ray Computed / methods
Ultrasonography / methods
Reg. No./Substance:
0/Coagulants; EC

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