| The use of tetracyclines for the treatment of sarcoidosis. | |
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MedLine Citation:
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PMID: 11176663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To evaluate the safety and efficacy of minocycline in the treatment of sarcoidosis, a nonrandomized, open study was performed in patients with cutaneous sarcoidosis. OBSERVATIONS: Twelve patients with cutaneous sarcoidosis were treated with minocycline, 200 mg/d, for a median duration of 12 months. Three patients had extracutaneous lesions at the time of the study. The median follow-up was 26 months. A clinical response was observed in 10 patients, consisting of complete responses in 8 patients and partial responses in 2 patients. A progression of skin lesions was observed in 1 patient, and lesions remained stable in another patient. Adverse effects were minimal, except in 1 patient, who developed hypersensitivity syndrome. A slight hyperpigmentation occurred in 2 patients at the site of previous lesions, which completely disappeared after minocycline use was discontinued. A relapse of skin symptoms occurred after minocycline withdrawal in 3 patients, who further received doxycycline, 200 mg/d, allowing a complete remission of lesions. CONCLUSIONS: These results support that minocycline and doxycycline may be beneficial for the treatment of cutaneous sarcoidosis. Randomized controlled studies are warranted for the evaluation of the true efficacy of tetracyclines in these patients. |
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Authors:
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H Bachelez; P Senet; J Cadranel; A Kaoukhov; L Dubertret |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 137 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-03-29 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 69-73 Citation Subset: AIM; IM |
Affiliation:
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Institut de Recherche sur la Peau et Service de Dermatologie 1, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France. herve.bachelez@sls.ap-hop-paris.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Bacterial Agents / therapeutic use* Arm Female Follow-Up Studies Forehead Humans Male Middle Aged Minocycline / therapeutic use* Sarcoidosis / drug therapy*, pathology Sarcoidosis, Pulmonary / drug therapy, radiography Skin Diseases / drug therapy*, pathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 10118-90-8/Minocycline |
| Comments/Corrections | |
Comment In:
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Arch Dermatol. 2001 Sep;137(9):1250
[PMID:
11559229
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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