Document Detail


The use of tetracyclines for the treatment of sarcoidosis.
MedLine Citation:
PMID:  11176663     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To evaluate the safety and efficacy of minocycline in the treatment of sarcoidosis, a nonrandomized, open study was performed in patients with cutaneous sarcoidosis. OBSERVATIONS: Twelve patients with cutaneous sarcoidosis were treated with minocycline, 200 mg/d, for a median duration of 12 months. Three patients had extracutaneous lesions at the time of the study. The median follow-up was 26 months. A clinical response was observed in 10 patients, consisting of complete responses in 8 patients and partial responses in 2 patients. A progression of skin lesions was observed in 1 patient, and lesions remained stable in another patient. Adverse effects were minimal, except in 1 patient, who developed hypersensitivity syndrome. A slight hyperpigmentation occurred in 2 patients at the site of previous lesions, which completely disappeared after minocycline use was discontinued. A relapse of skin symptoms occurred after minocycline withdrawal in 3 patients, who further received doxycycline, 200 mg/d, allowing a complete remission of lesions. CONCLUSIONS: These results support that minocycline and doxycycline may be beneficial for the treatment of cutaneous sarcoidosis. Randomized controlled studies are warranted for the evaluation of the true efficacy of tetracyclines in these patients.
Authors:
H Bachelez; P Senet; J Cadranel; A Kaoukhov; L Dubertret
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  137     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-29     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  AIM; IM    
Affiliation:
Institut de Recherche sur la Peau et Service de Dermatologie 1, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France. herve.bachelez@sls.ap-hop-paris.fr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Bacterial Agents / therapeutic use*
Arm
Female
Follow-Up Studies
Forehead
Humans
Male
Middle Aged
Minocycline / therapeutic use*
Sarcoidosis / drug therapy*,  pathology
Sarcoidosis, Pulmonary / drug therapy,  radiography
Skin Diseases / drug therapy*,  pathology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 10118-90-8/Minocycline
Comments/Corrections
Comment In:
Arch Dermatol. 2001 Sep;137(9):1250   [PMID:  11559229 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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