| The use of sustained release delivery of chlorhexidine for the maintenance of periodontal pockets: 2-year clinical trial. | |
| | |
MedLine Citation:
|
PMID: 1920009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The release of chlorhexidine from an ethyl cellulose-based dosage form (SRD) has been shown to be effective in the reduction of the flora associated with periodontal pockets as well as in reducing probing depths. In this study, treatment with this dosage form was compared to routine maintenance therapy (RMT) in a 2-year, split mouth clinical trial. Ten patients with 84 pockets greater than or equal to 5 mm who had not received any periodontal therapy or systemic antibiotics over the last 6 months were included. The patients all received a full mouth scaling and root planing together with through oral hygiene instruction. Two months later (baseline) plaque index (P1I), bleeding on probing (BOP), pocket probing depth (PD), and attachment levels (AL) were assessed at all selected sites. Pockets on the control side then received RMT while the experimental pockets were treated with the SRD only. Treatment was repeated every 3 months for 2 years. The SRD treatment resulted in an improvement of greater than or equal to 3 mm in PD of at least 1 pocket in 8 of 10 patients, while RMT resulted in a similar improvement in only 1 of 10 patients (P = 0.012). Similarly a gain of attachment of greater than or equal to 3 mm was found in at least 1 SRD pocket in 8 of 10 patients. The RMT resulted in a similar improvement in only 2 patients (P = 0.012).(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
A Stabholz; W A Soskolne; M Friedman; M N Sela |
Related Documents
:
|
19356319 - Systematic review of periodontal plastic surgery in the treatment of multiple recession... 7891249 - The effect of a single application of subgingival antimicrobial or mechanical therapy o... 15119889 - Clinical and radiographic evaluation of emdogain as a regenerative material in the trea... 18974539 - The effect of povidone-iodine and chlorhexidine mouth rinses on plaque streptococcus mu... 3308969 - 4 modalities of periodontal treatment compared over 5 years. 19478489 - Prevention of preterm delivery with periodontal treatment. 8815569 - A fixed-dose combination of low molecular weight heparin with dihydroergotamine versus ... 22014299 - Placement technique of extended spreader grafts. 11558979 - Interindividual differences in the analgesic response to ketamine in chronic orofacial ... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of periodontology Volume: 62 ISSN: 0022-3492 ISO Abbreviation: J. Periodontol. Publication Date: 1991 Jul |
Date Detail:
|
Created Date: 1991-11-18 Completed Date: 1991-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 429-33 Citation Subset: D; IM |
Affiliation:
|
Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cellulose / analogs & derivatives Chlorhexidine / administration & dosage, therapeutic use* Delayed-Action Preparations Dental Plaque / prevention & control Dental Plaque Index Dental Prophylaxis Dental Scaling Epithelial Attachment / pathology Female Gingival Hemorrhage / prevention & control Humans Male Oral Hygiene Periodontal Index Periodontal Pocket / drug therapy*, pathology, therapy Root Planing |
| Chemical | |
Reg. No./Substance:
|
0/Delayed-Action Preparations; 55-56-1/Chlorhexidine; 9004-34-6/Cellulose; 9004-57-3/ethyl cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dentinal tubule occlusion and root hypersensitivity.
Next Document: The effect of chlorhexidine treatment of root surfaces on the attachment of human gingival fibroblas...