| The use of surfactants in 2009. | |
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MedLine Citation:
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PMID: 19460896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Surfactant replacement therapy has been available for about 25 years, revolutionising neonatal respiratory care after its introduction in the 1980s. Along with antenatal steroids, surfactants improve survival for preterm babies and they are now recommended routinely as early in the course of respiratory distress syndrome (RDS) as possible. Prophylactic treatment, although appearing ideal, exposes some babies who might manage perfectly well on continuous positive airway pressure (CPAP) to intubation and ventilation, which may increase the risk of bronchopulmonary dysplasia. Recent studies attempt to determine the optimal balance between avoiding ventilation by using CPAP and giving surfactant in a timely fashion to babies with RDS. Surfactants are also used for conditions other than RDS, such as meconium aspiration, pulmonary haemorrhage and pneumonia, although the evidence base for their use in these indications is much weaker. Recently, surfactants have been used to deliver steroids directly to the lungs and this seems to be a promising technique worthy of further study. Finally, the quest goes on to develop a synthetic product that can match the effects of animal derived natural surfactants and could be produced at lower cost. |
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Authors:
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D G Sweet; H L Halliday |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Archives of disease in childhood. Education and practice edition Volume: 94 ISSN: 1743-0593 ISO Abbreviation: Arch Dis Child Educ Pract Ed Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-22 Completed Date: 2009-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101220684 Medline TA: Arch Dis Child Educ Pract Ed Country: England |
Other Details:
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Languages: eng Pagination: 78-83 Citation Subset: IM |
Affiliation:
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Regional Neonatal Unit, Royal Maternity Hospital, Belfast BT12 6BJ, Northern Ireland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Infant, Newborn Pulmonary Surfactants / therapeutic use* Respiratory Distress Syndrome, Newborn / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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