Document Detail


On the use of strong Patterson function signals in many-body molecular replacement.
MedLine Citation:
PMID:  9757095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The symmetry elements detected by the self-rotation and the Patterson functions, associated to strong correlations between the positions of the molecules in the asymmetric unit, are used to reduce the effective number of independent bodies to be located by the molecular replacement method. A distinction is made between 'frustrated' crystallographic symmetries, i.e. those that are almost crystallographic ones, and 'standard' non-crystallographic symmetries, which are taken into account by specific techniques. These have been successfully applied to many-body macromolecular crystal structures, with important savings in time and computational effort.
Authors:
J Navaza; E H Panepucci; C Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta crystallographica. Section D, Biological crystallography     Volume:  54     ISSN:  0907-4449     ISO Abbreviation:  Acta Crystallogr. D Biol. Crystallogr.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-14     Completed Date:  1998-12-14     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  9305878     Medline TA:  Acta Crystallogr D Biol Crystallogr     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  817-21     Citation Subset:  IM    
Affiliation:
ERS 582 du CNRS, Laboratoire de Physique, Centre d'Etudes Pharmaceutiques. 92290 Chatenay-Malabry, France. jorge.navaza@cep.u-psud.fr
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MeSH Terms
Descriptor/Qualifier:
Bacillus / chemistry
Bacterial Proteins / chemistry
Crystallization
Crystallography, X-Ray*
Enzyme Inhibitors / chemistry
Immunoglobulin Fab Fragments / chemistry
Mathematics
Models, Molecular*
Molecular Structure*
Protein Conformation
Rotation
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Enzyme Inhibitors; 0/Immunoglobulin Fab Fragments; 37328-61-3/barstar protein, Bacillus amyloliquefaciens

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