| On the use of strong Patterson function signals in many-body molecular replacement. | |
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MedLine Citation:
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PMID: 9757095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The symmetry elements detected by the self-rotation and the Patterson functions, associated to strong correlations between the positions of the molecules in the asymmetric unit, are used to reduce the effective number of independent bodies to be located by the molecular replacement method. A distinction is made between 'frustrated' crystallographic symmetries, i.e. those that are almost crystallographic ones, and 'standard' non-crystallographic symmetries, which are taken into account by specific techniques. These have been successfully applied to many-body macromolecular crystal structures, with important savings in time and computational effort. |
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Authors:
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J Navaza; E H Panepucci; C Martin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta crystallographica. Section D, Biological crystallography Volume: 54 ISSN: 0907-4449 ISO Abbreviation: Acta Crystallogr. D Biol. Crystallogr. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-12-14 Completed Date: 1998-12-14 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 9305878 Medline TA: Acta Crystallogr D Biol Crystallogr Country: DENMARK |
Other Details:
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Languages: eng Pagination: 817-21 Citation Subset: IM |
Affiliation:
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ERS 582 du CNRS, Laboratoire de Physique, Centre d'Etudes Pharmaceutiques. 92290 Chatenay-Malabry, France. jorge.navaza@cep.u-psud.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacillus
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chemistry Bacterial Proteins / chemistry Crystallization Crystallography, X-Ray* Enzyme Inhibitors / chemistry Immunoglobulin Fab Fragments / chemistry Mathematics Models, Molecular* Molecular Structure* Protein Conformation Rotation |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Enzyme Inhibitors; 0/Immunoglobulin Fab Fragments; 37328-61-3/barstar protein, Bacillus amyloliquefaciens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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