Document Detail


The use of statins potentiates the insulin-sensitizing effect of exercise training in obese males with and without Type 2 diabetes.
MedLine Citation:
PMID:  20465545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise training is advocated in insulin resistance and statins are used to treat hyperlipidaemia, two cardiometabolic risk factors often presenting concurrently. Statin intake may blunt mitochondrial function and the adaptive response to exercise training. Thus combining exercise training with statin administration may have adverse effects. We examined whether improvements in cardiometabolic risk factors, insulin sensitivity and mitochondrial function mediated by progressive exercise training are affected by statin use. A group of 14 obese elderly males on statins (ST) and 22 matched control subjects (C) were examined. Results on in vivo mitochondrial function [MRS (magnetic resonance spectroscopy)], mitochondrial density (Western blotting), insulin sensitivity (clamp) and metabolic flexibility (indirect calorimetry) were compared before and after a 12-week combined progressive exercise training programme (3 x per week; 45 min per session). Except for LDL (low-density lipoprotein) cholesterol, all pre-training values were comparable between statin users and control subjects. In vivo mitochondrial function and mitochondrial density improved by training in both groups. Interestingly, blood-lipid profile, insulin sensitivity (+72%), non-oxidative and oxidative glucose disposal (+38% and +112%) and insulin-mediated suppression of fat oxidation (-62%) improved only in the ST group. We conclude that statin treatment did not impede exercise performance or tolerance, mitochondrial function or mass. In addition, training-induced improvements in glucose homoeostasis were preserved in the ST group. Strikingly, the insulin-sensitizing effect of training was more prominent in the ST group than in the C group. The combined prescription of statins along with exercise training is safe and should be considered for subjects prone to develop insulin resistance.
Authors:
Ruth C R Meex; Esther Phielix; Vera B Schrauwen-Hinderling; Esther Moonen-Kornips; Gert Schaart; Patrick Schrauwen; Matthijs K C Hesselink
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-25
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  119     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-06-25     Completed Date:  2010-09-16     Revised Date:  2010-09-23    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  293-301     Citation Subset:  IM    
Affiliation:
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Combined Modality Therapy
Diabetes Mellitus, Type 2 / blood,  physiopathology,  therapy*
Exercise / physiology
Exercise Therapy / methods
Exercise Tolerance / physiology
Glucose Clamp Technique / methods
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects,  therapeutic use*
Insulin / blood
Insulin Resistance
Lipids / blood
Male
Metabolic Syndrome X / blood,  physiopathology,  therapy*
Middle Aged
Mitochondria, Muscle / physiology
Obesity / blood,  physiopathology,  therapy*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 11061-68-0/Insulin

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