Document Detail

The use of split-thickness skin as an autogenous arterial conduit.
MedLine Citation:
PMID:  3056485     Owner:  NLM     Status:  MEDLINE    
Eight mongrel dogs were anesthetized using general anesthesia, and graft consisting of split-thickness skin obtained from their abdomen was devised and inserted in each of their infrarenal aortas. Six of the grafts were reinforced with meshed polytetrafluoroethylene (PTFE) as an outer layer to prevent potential aneurysmal dilatation of the skin graft. None of the dogs received aspirin at any time. The dogs were sacrificed at one, four, and six weeks. The grafts were examined with light microscopy and three of them were analyzed with scanning electron microscope. All grafts remained patent and none formed aneurysmal dilatations. None of the dogs developed infections or aortoenteric fistulas. Of the three grafts that showed thrombus-free areas, all were oriented with the epidermis facing the lumen. The three grafts where the epidermis formed the external surface did not degenerate in any area. Endothelium-like cells continuous with the host vessel were present on all grafts at 4 and 6 weeks by light or scanning electron microscopy. Preliminary data from this study indicated that split-thickness skin may be a suitable arterial conduit. Even if it does not prove to have long-term patency rates, it may be a suitable temporary conduit until infections resolve and synthetic prostheses can be reinserted.
K D Calligaro; D L Rollins; M L Friedell; C M Semrow; D Buchbinder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  2     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-01-12     Completed Date:  1989-01-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Department of Surgery, University of Health Sciences/Chicago Medical School, Illinois 60064.
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MeSH Terms
Aorta, Abdominal / cytology,  surgery
Blood Vessel Prosthesis*
Endothelium / cytology
Endothelium, Vascular / cytology
Skin Transplantation*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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