| On the use of a spin-echo based double inversion recovery acquisition for the measurement of cortical brain thickness. | |
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MedLine Citation:
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PMID: 21509881 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To determine whether a spin-echo-based sequence, which are inherently insensitive to magnetic field inhomogeneity, can be used for brain cortical thickness measurement studies. MATERIALS AND METHODS: By using a double inversion recovery (DIR) spin-echo-based sequence, cortical thickness estimates were performed from data acquired from seven healthy volunteers. The cortical thickness was also calculated from data acquired using an MPRAGE sequence and the Bland-Altman analysis was performed for comparison of the two methods. The average signal and contrast to noise ratios (SNR, CNR) of the two methods were also calculated. RESULTS: The bias over the entire brain between DIR and MPRAGE was 0.87 ± 0.08 mm. The bias calculated in the major regional lobes were temporal: 0.76 ± 0.09 mm, frontal: 0.89 ± 0.07 mm, parietal: 0.92 ± 0.10 mm, occipital: 0.75 ± 0.12 mm, and cingulate: 0.79 ± 0.10 mm. This thickness difference was due mainly to the boundary difference in the MPRAGE and DIR at the grey matter/cerebral spinal fluid (GM/CSF) regions. The mean SNR and CNR was CNR(MPRAGE) = 47.8 ± 8.4 and CNR(DIR) = 19.2 ± 2.9, SNR(MPRAGE) = 76.8 ± 10.5 and SNR(DIR) = 21.1 ± 2.8. CONCLUSION: The study suggests that cortical thickness measurements can be performed using a DIR spin-echo sequence, which is inherently immune to main field inhomogeneity. Larger thickness measurements were consistently observed in DIR compared with MPRAGE. J. Magn. Reson. Imaging 2011;33:1218-1223. © 2011 Wiley-Liss, Inc. |
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Authors:
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Yoonho Nam; Eung Yeop Kim; Dong-Hyun Kim |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 33 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1218-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Yonsei University, Department of Electrical and Electronic Engineering, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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