Document Detail

The use of soy protein isolate to reduce the severity of 13-cis retinoic acid-induced hypertriglyceridemia.
MedLine Citation:
PMID:  9824375     Owner:  NLM     Status:  MEDLINE    
The ability of soy protein isolate to reduce the severity of 13-cis retinoic acid (13cRA)-induced hypertriglyceridemia was assessed in an animal model of this condition (rats fed a 13cRA-containing, casein-based diet). Male Fischer 344 rats (N = 7/group) were fed purified diets containing either casein or soy protein isolate and having either no 13cRA or retinoid at a level of 100 mg/kg diet-designated as Groups C, S, C + R, and S + R, respectively. Diet had no effect on either food intake or final body weight, and the serum levels of 13cRA were not significantly different for Groups C + R and S + R. Groups fed diets having 13cRA had significantly (p < 0.05) higher serum triglyceride levels than ones fed the corresponding retinoid-free diets, but the serum triglyceride level for Group S + R was significantly lower than for Group C + R, being 2.99 vs. 6.97 mM (265 vs. 617 mg/dl). Thus, soy protein isolate can reduce the severity of 13cRA-induced hypertriglyceridemia without affecting serum retinoid level.
J D Radcliffe; V L Imrhan; A M Hsueh
Related Documents :
2236105 - The effect of dietary protein source on manganese bioavailability to the rat.
12618915 - The soya isoflavone content of rat diet can increase anxiety and stress hormone release...
20205965 - Daidzein-metabolising phenotypes in relation to serum lipids and uric acid in adults in...
14672755 - Soy protein diet ameliorates renal nitrotyrosine formation and chronic nephropathy indu...
17475345 - Am 251 and beta-funaltrexamine reduce fat intake in a fat-preferring strain of mouse.
22857825 - Exclusive elemental diet impacts on the gastrointestinal microbiota and improves sympto...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer detection and prevention     Volume:  22     ISSN:  0361-090X     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  1998  
Date Detail:
Created Date:  1999-06-17     Completed Date:  1999-06-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  526-32     Citation Subset:  IM    
Department of Nutrition and Food Sciences, Texas Woman's University, Houston 77030, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Hypertriglyceridemia / chemically induced*,  prevention & control*
Isotretinoin / pharmacology*
Rats, Inbred F344
Soybean Proteins / therapeutic use*
Reg. No./Substance:
0/Soybean Proteins; 4759-48-2/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Screening for in vitro anti-tumor-promoting activities of edible plants from Indonesia.
Next Document:  A meta-analysis of painting exposure and cancer mortality.