Document Detail


The use of soy protein isolate to reduce the severity of 13-cis retinoic acid-induced hypertriglyceridemia.
MedLine Citation:
PMID:  9824375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of soy protein isolate to reduce the severity of 13-cis retinoic acid (13cRA)-induced hypertriglyceridemia was assessed in an animal model of this condition (rats fed a 13cRA-containing, casein-based diet). Male Fischer 344 rats (N = 7/group) were fed purified diets containing either casein or soy protein isolate and having either no 13cRA or retinoid at a level of 100 mg/kg diet-designated as Groups C, S, C + R, and S + R, respectively. Diet had no effect on either food intake or final body weight, and the serum levels of 13cRA were not significantly different for Groups C + R and S + R. Groups fed diets having 13cRA had significantly (p < 0.05) higher serum triglyceride levels than ones fed the corresponding retinoid-free diets, but the serum triglyceride level for Group S + R was significantly lower than for Group C + R, being 2.99 vs. 6.97 mM (265 vs. 617 mg/dl). Thus, soy protein isolate can reduce the severity of 13cRA-induced hypertriglyceridemia without affecting serum retinoid level.
Authors:
J D Radcliffe; V L Imrhan; A M Hsueh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer detection and prevention     Volume:  22     ISSN:  0361-090X     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  1998  
Date Detail:
Created Date:  1999-06-17     Completed Date:  1999-06-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  526-32     Citation Subset:  IM    
Affiliation:
Department of Nutrition and Food Sciences, Texas Woman's University, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemoprevention
Hypertriglyceridemia / chemically induced*,  prevention & control*
Isotretinoin / pharmacology*
Male
Rats
Rats, Inbred F344
Soybean Proteins / therapeutic use*
Chemical
Reg. No./Substance:
0/Soybean Proteins; 4759-48-2/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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