| The use of small-bowel capsule endoscopy in iron-deficiency anemia alone; be aware of the young anemic patient. | |
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MedLine Citation:
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PMID: 22852553 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background & aim. The role of Small-Bowel Capsule Endoscopy (SBCE) in Iron Deficiency Anemia (IDA) alone is still under validation. We aim to assess the usefulness of SBCE in patients with IDA alone; Methods. Retrospective study; patients with IDA (no GI symptoms or known previous diagnosis), who underwent SBCE were included. SBCE findings were classified as clinically significant/sinister (small-bowel malignancy, significant/sinister inflammation and/or strictures and coeliac disease) or vascular, i.e., signifcant/angioectasias (P1/P2 lesions); Results. A total of 221 (151F/70M) patients had SBCE for IDA as the sole indication. The diagnostic yield (DY) was 30.7% (68/221). The DY for significant/sinister pathology and significant/angioectasias was 9% and 21.7%, respectively. In those ≤40 years (20; 13F/7M), significant pathology was found in 25% (5/20); in the >40-year group (201; 138F/63M), significant/sinister pathology was found in 7.5% (15/201), p = 0.0231. None of the patients ≤40 years had angioectasias, such lesions were found in 48/201 (21.7%) of those >40 years, p = 0.009. Fifty percent of those >80 years (16; 12F/4M) had angioectasias, but none had significant/sinister pathology (p = 0.0126). On multiple regression analysis, only prior blood transfusion was predictive of higher DY in SBCE; Conclusions. IDA alone is one of the main indications (27%) for referral to SBCE; the majority of patients are >40 years. In our cohort, the DY of SBCE for IDA was 30.7% and the commonest finding was angioectasias. The detection rate of sinister small-bowel pathology for those >40 years is low decreasing to zero in the >80 age group. In contrast, 25% of those ≤40 years had a sinister diagnosis. |
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Authors:
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Anastasios Koulaouzidis; Diana E Yung; Jeff H P Lam; Alexandros Smirnidis; Sarah Douglas; John N Plevris |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-2 |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: - ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre for Liver & Digestive Disorders, The Royal Infirmary of Edinburgh , Edinburgh , UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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