Document Detail

The use of serial CA 125 concentrations to monitor endometriosis in infertile women.
MedLine Citation:
PMID:  2403129     Owner:  NLM     Status:  MEDLINE    
To evaluate the potential use of CA 125 concentrations in monitoring women with endometriosis, serial determinations were correlated with the clinical course of the disease and pregnancy rates. Preoperative CA 125 concentrations were obtained in 134 consecutive infertile women with endometriosis. Seventy-six (57%) women had values greater than or equal to 16 U/ml and were followed up for 18 months. At the 6-, 12-, and 18-month intervals, pregnancies occurred in 18 of 45 (30%), 14 of 24 (58%), and 5 of 12 (42%) women in the good prognosis group, respectively; pregnancy rates in the poor prognosis group were 1 of 31 (3%), 2 of 33 (6%), and 0 of 26 (0%) women (p less than 0.001). Changes in the CA 125 values correlated with the surgical findings in 24 of the 26 women (92%) who had a second-look operative procedure. The study supports the use of serial CA 125 concentrations to assist in the management of women with endometriosis.
D E Pittaway
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  163     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-24     Completed Date:  1990-10-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1032-5; discussion 1035-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
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MeSH Terms
Antigens, Tumor-Associated, Carbohydrate / analysis*
Endometriosis / diagnosis,  immunology*,  therapy
Infertility, Female / immunology*,  therapy
Predictive Value of Tests
Pregnancy Tests
Prospective Studies
Reg. No./Substance:
0/Antigens, Tumor-Associated, Carbohydrate

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