| The use of semen parameters to identify the subfertile male in the general population. | |
| | |
MedLine Citation:
|
PMID: 15572878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To present a structured review of the literature published on semen parameters and in vivo fertility potential and to establish fertility/subfertility thresholds for sperm morphology using Tygerberg strict criteria, sperm concentration, and sperm motility. METHOD: The published literature comparing fertile and subfertile populations between 1983 and 2002 was reviewed. RESULTS: A total of 265 articles were identified by the sourcing methodology, but only four articles provided data that could be tabulated and analyzed. Using receiver-operating characteristics curves, morphology proved to be the best predictor of subfertility in 2 of the 4 articles, with concentration and motility also showing good predictive power. The thresholds calculated ranged between 4 and 10% for morphology, between 13.5 x 10(6)/ml and 34 x 10(6)/ml for concentration, and between 32 and 52% for motility. A second set of much lower thresholds was calculated in three of the articles using either a 15 or 50% prevalence of subfertility in the population or the tenth percentile of the fertile population. The adjusted thresholds were between 3 and 5% for morphology, between 9 x 10(6)/ml and 20 x 10(6)/ml for concentration, and between 20 and 30% for motility. CONCLUSIONS: Because these lower thresholds have a much higher positive predictive value, we suggest that thresholds of <5% normal sperm morphology, a concentration <15 x 10(6)/ml, and a motility <30% should be used to identify the subfertile male. The lower threshold for morphology also fits in vitro fertilization and intrauterine insemination data calculated previously. Using the parameters in combination increases the clinical value of semen analysis. |
| | |
Authors:
|
F H van der Merwe; T F Kruger; S C Oehninger; C J Lombard |
Related Documents
:
|
9627308 - Successful pregnancy with sperm retrieved from the bladder after the introduction of a ... 15749488 - Etiology-specific outcomes of intracytoplasmic sperm injection in azoospermic patients. 15986748 - The effect of penile vibratory stimulation on male fertility potential, spasticity and ... 11297068 - Pregnancy rates in relation to time intervals between repeat sperm-retrieval procedures. 18689148 - Heterotropic pregnancy: a report of two cases. 8612858 - Midluteal buserelin is superior to early follicular phase buserelin in combined gonadot... |
Publication Detail:
|
Type: Journal Article; Review Date: 2004-11-29 |
Journal Detail:
|
Title: Gynecologic and obstetric investigation Volume: 59 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2005 |
Date Detail:
|
Created Date: 2005-02-15 Completed Date: 2005-05-26 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 86-91 Citation Subset: IM |
Copyright Information:
|
Copyright 2005 S. Karger AG, Basel. |
Affiliation:
|
Reproductive Biology Unit, Department of Obstetrics and Gynecology, University of Stellenbosch and Tygerberg Hospital, Tygerberg, South Africa. hkr@sun.ac.za |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Fertility* Humans Infertility, Male* / pathology, physiopathology Male Predictive Value of Tests Reference Values Semen / cytology* Sensitivity and Specificity Sperm Motility* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Executive function impairment in community elderly subjects with questionable dementia.
Next Document: Interactions between nitric oxide and arachidonic acid in lung epithelial cells: possible roles for ...