Document Detail

The use of selective serotonin reuptake inhibitors in pregnancy.
MedLine Citation:
PMID:  15361279     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To provide an update of literature on the safety of using selective serotonin reuptake inhibitors (SSRIs) during pregnancy. METHODS: MEDLINE was searched for English-language papers published from 1985 to 2003 on human studies of SSRIs, using the key words "serotonin reuptake inhibitors," "citalopram," "fluoxetine," "fluvoxamine," "paroxetine," and "sertraline." RESULTS: The literature search yielded 12 338 publications. Previous studies on the safety of SSRIs in pregnancy were often based on small samples from medical centres, with heterogeneous design and outcome ascertainment methods, and had yielded inconsistent results. Consequently, the management of pregnant women with depression poses challenges to clinicians who are hesitant to prescribe anti-depression drugs, including SSRIs, because of concern about potential risks to the fetuses. Failure to adequately treat maternal depression can lead to progressively worsening depression that greatly compromises maternal-fetal health and can impair bonding and childcare in the postpartum period. CONCLUSIONS: Because of the uncertainty regarding the safety of SSRI use during pregnancy, consultation with specialists experienced in treating depression may be helpful when treating pregnant women with SSRIs. Large-scale, population-based studies to comprehensively assess the safety of SSRIs in pregnancy are needed.
Shi Wu Wen; Mark Walker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC     Volume:  26     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-13     Completed Date:  2005-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  819-22     Citation Subset:  IM    
OMNI Research Group, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Ottawa, Ottawa ON.
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MeSH Terms
Depression / drug therapy*
Pregnancy Complications / drug therapy*
Serotonin Uptake Inhibitors / therapeutic use*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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