Document Detail

The use of selective serotonin reuptake inhibitors during pregnancy and lactation: current knowledge.
MedLine Citation:
PMID:  10779887     Owner:  NLM     Status:  MEDLINE    
This article reviews the effects of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants in pregnant and lactating women for the treatment of depression and anxiety disorders. An examination of the literature was conducted using Medline (1966 to present). Despite methodological concerns and the scarcity of data on this important subject, the majority of recent investigations demonstrate safety of the fetus exposed to SSRIs during pregnancy. All of the SSRIs reported in the studies are excreted into breast milk, and low levels have been found in infant serum. The implications of this for practice include identifying the effects of treatment versus nontreatment on the mother-infant dyad. Further research must examine long-term neurobehavioural teratogenicity in exposed infants.
S Misri; D Kostaras; X Kostaras
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of psychiatry. Revue canadienne de psychiatrie     Volume:  45     ISSN:  0706-7437     ISO Abbreviation:  Can J Psychiatry     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-17     Completed Date:  2000-05-17     Revised Date:  2007-08-01    
Medline Journal Info:
Nlm Unique ID:  7904187     Medline TA:  Can J Psychiatry     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  285-7     Citation Subset:  IM    
Department of Psychiatry, University of British Columbia, Vancouver.
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MeSH Terms
Depressive Disorder / drug therapy*
Lactation / drug effects*
Prospective Studies
Risk Factors
Serotonin Uptake Inhibitors / therapeutic use*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors
Comment In:
Can J Psychiatry. 2001 May;46(4):371   [PMID:  11387796 ]
Can J Psychiatry. 2000 Dec;45(10):939-40   [PMID:  11190370 ]
Can J Psychiatry. 2001 Jun;46(5):452   [PMID:  11441786 ]
Can J Psychiatry. 2000 Dec;45(10):940   [PMID:  11190371 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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