Document Detail

The use of the selective serotonin S2 receptor antagonist Ketanserin in the treatment of Raynaud's phenomenon.
MedLine Citation:
PMID:  3075559     Owner:  NLM     Status:  MEDLINE    
Ketanserin, a selective S2-receptor antagonist was evaluated in a double-blind parallel placebo-controlled trial of 29 patients with Raynaud's phenomenon. The effect on finger blood flow was assessed by strain-gauge plethysmography during a standardised cooling stress. Ten normal healthy controls also had finger blood flow assessments made in the same way. The Ketanserin group showed a significantly greater improvement (P less than 0.05) in finger blood flow at minimum flow temperature than the placebo group. The results suggest that the local release of serotonin may play a role in Raynaud's phenomenon and that Ketanserin can modify the abnormal response in finger blood flow.
J A Dormandy; A Berent; S J Downes
Related Documents :
24863699 - Assessment of pulmonary vascular reactivity to oxygen using fractional moving blood vol...
7592199 - Effect of microgravity on forearm subcutaneous vascular resistance in humans.
11605769 - Transdermal estrogen replacement therapy and vasomotor response.
7810709 - Effects of endothelium-derived nitric oxide on skin and digital blood flow in humans.
21332759 - Levels of matrix metalloproteinase-2 and -9 in the cerebrospinal fluid of dogs with vis...
18369659 - Changes in blood flow in conduit artery and veins of the upper arm during leg exercise ...
14598109 - Flow study on a newly developed impeller for a left ventricular assist device.
3893199 - Lowering of blood acetaldehyde but not ethanol concentrations by pantethine following a...
15043589 - Evaluation of the future supply and demand for blood products in the united kingdom nat...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of vascular surgery     Volume:  2     ISSN:  0950-821X     ISO Abbreviation:  Eur J Vasc Surg     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709440     Medline TA:  Eur J Vasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  371-5     Citation Subset:  IM    
Department of Vascular Surgery, St James' Hospital, London, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Flow Velocity / drug effects
Clinical Trials as Topic
Double-Blind Method
Fingers / blood supply
Ketanserin / therapeutic use*
Middle Aged
Raynaud Disease / drug therapy*,  physiopathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Food intake of infant rats after intraperitoneal administration of insulin.
Next Document:  Ultrasonic duplex scanning of the prevertebral segment of the vertebral artery in patients with cere...