Document Detail


The use of the selective serotonin S2 receptor antagonist Ketanserin in the treatment of Raynaud's phenomenon.
MedLine Citation:
PMID:  3075559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ketanserin, a selective S2-receptor antagonist was evaluated in a double-blind parallel placebo-controlled trial of 29 patients with Raynaud's phenomenon. The effect on finger blood flow was assessed by strain-gauge plethysmography during a standardised cooling stress. Ten normal healthy controls also had finger blood flow assessments made in the same way. The Ketanserin group showed a significantly greater improvement (P less than 0.05) in finger blood flow at minimum flow temperature than the placebo group. The results suggest that the local release of serotonin may play a role in Raynaud's phenomenon and that Ketanserin can modify the abnormal response in finger blood flow.
Authors:
J A Dormandy; A Berent; S J Downes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of vascular surgery     Volume:  2     ISSN:  0950-821X     ISO Abbreviation:  Eur J Vasc Surg     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709440     Medline TA:  Eur J Vasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  371-5     Citation Subset:  IM    
Affiliation:
Department of Vascular Surgery, St James' Hospital, London, U.K.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Flow Velocity / drug effects
Clinical Trials as Topic
Double-Blind Method
Female
Fingers / blood supply
Humans
Ketanserin / therapeutic use*
Male
Middle Aged
Raynaud Disease / drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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