Document Detail

The use of sedative agents in critically ill patients.
MedLine Citation:
PMID:  1377117     Owner:  NLM     Status:  MEDLINE    
The main aim of sedation in the critically ill patient is to provide relief from anxiety and pain. The current, ideal level of sedation should leave a patient who is lightly asleep but easily roused. No single regimen is suitable for all patients. The level of sedation should be monitored, and the choice of agent, the dose and the route of administration adjusted appropriately. Midazolam is often used to provide sleep and anxiolysis. Alternatives include propofol and isoflurane. Propofol is easily titrated to achieve the desired level of sedation, and its effects rapidly end when the infusion is stopped. Isoflurane also appears promising, but special equipment is needed for its administration. Morphine is the standard analgesic agent. The principal metabolites, morphine-6-glucuronide, is also a potent opioid agonist and may accumulate in renal failure. Of the newer analgesic agents, alfentanil is an ideal agent for infusion, and may be the agent of choice in renal failure. Neuromuscular blocking agents are indicated only in specific circumstances, and used only once it is known patients are asleep and pain free. The actions of these agents are unpredictable in the critically ill patient. Alterations in drug effect and elimination may occur, especially in the patient with hepatic and renal failure. This may also apply to active metabolites of the parent drug. When planning sedation regimens, specific patient needs and staffing levels must be remembered. Attention to the environment is also important. Midazolam and morphine given by intermittent bolus or by infusion are the mainstay of most regimens. Propofol is ideal for short periods of care on the ICU, and during weaning when longer acting agents are being eliminated.
A M Burns; M P Shelly; G R Park
Related Documents :
17496007 - Prevalence, challenges, and solutions for (18)f-fdg pet studies of obese patients: a te...
7048037 - Fentanyl and diazepam in endoscopy of the upper gastrointestinal tract.
11505347 - Target-controlled infusion or manually controlled infusion of propofol in high-risk pat...
3159407 - Comparison of diazepam and midazolam for sedation during local anaesthesia for bronchos...
2444937 - A prospective evaluation of single and dual current pathways for transvenous cardiovers...
19338587 - Chromated metal products may be hazardous to patients with chromate allergy.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  43     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  507-15     Citation Subset:  IM    
John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, England.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Critical Care*
Hypnotics and Sedatives / therapeutic use*
Reg. No./Substance:
0/Hypnotics and Sedatives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cancer-associated anorexia and cachexia. Implications for drug therapy.
Next Document:  Recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF). A review of its pharmacologi...