Document Detail

The use of retinoids in the treatment of photoaging.
MedLine Citation:
PMID:  17014485     Owner:  NLM     Status:  MEDLINE    
Photoaging describes the clinical and histologic consequences of chronic sun exposure, the key features of which--wrinkles and mottled hyperpigmentation--are frequently and erroneously attributed to the aging process. Although a number of surgical procedures can improve the clinical appearance of photoaged skin, the only medical therapy with proved benefit derived from randomized clinical trial evidence is the use of topical retinoids, particularly tretinoin, isotretinoin, and tazarotene. Retinoids are capable not only of repairing photoaged skin at both the clinical and biochemical levels but their use may prevent photoaging. There is in addition emerging evidence that topical retinoids could be beneficial in the treatment of intrinsically aged skin.
Minal Singh; Christopher E M Griffiths
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Dermatologic therapy     Volume:  19     ISSN:  1396-0296     ISO Abbreviation:  Dermatol Ther     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-10-03     Completed Date:  2007-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9700070     Medline TA:  Dermatol Ther     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  297-305     Citation Subset:  IM    
Dermatopharmacology Unit, The Dermatology Center, University of Manchester, Hope Hospital, Manchester, UK.
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MeSH Terms
Administration, Topical
Retinoids / administration & dosage*
Skin Aging / drug effects*
Skin Diseases / drug therapy,  etiology
Treatment Outcome
Reg. No./Substance:

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