Document Detail

The use of rest and exercise radionuclide ventriculography in risk stratification in patients with suspected coronary artery disease.
MedLine Citation:
PMID:  3876759     Owner:  NLM     Status:  MEDLINE    
The study examined the value of rest and exercise radionuclide ventriculography in risk stratification in patients with suspected coronary artery disease. There were 604 patients, 474 men and 130 women, aged 55 +/- 11 years (mean +/- standard deviation). At a follow-up of 18 +/- 10 months, there were 43 hard cardiac events: 27 patients died of cardiac causes and 16 had nonfatal acute myocardial infarctions. Univariate and multivariate survival analysis of the 10 most important clinical and exercise variables identified the exercise left ventricular ejection fraction as the most important predictor of death and total cardiac events (chi 2 = 18.1 and 29.6, respectively). The exercise heart rate was a significant, independent, but much weaker predictor of cardiac death and total events (chi 2 = 8.4 and 3.9, respectively), while exercise tolerance was a significant independent predictor of cardiac death only (chi 2 = 6.4). Actuarial life table analysis showed that the risk for future cardiac events increased in stepwise fashion as the exercise ejection fraction decreased. Thus, the exercise left ventricular ejection fraction is a useful prognosticator in patients with suspected coronary artery disease. This finding has important implications in patient management.
A S Iskandrian; A H Hakki; I P Goel; E D Mundth; S A Kane-Marsch; C L Schenk
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  110     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-11-06     Completed Date:  1985-11-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  864-72     Citation Subset:  AIM; IM    
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MeSH Terms
Actuarial Analysis
Coronary Artery Bypass
Coronary Disease / radionuclide imaging*,  surgery
Exercise Test*
Follow-Up Studies
Heart Ventricles / radionuclide imaging
Middle Aged
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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