Document Detail

The use of radioactive microspheres to compare the effects of hydralazine, guanethidine and SK & F 24260 on the redistribution of cardiac output in anaesthetized rabbits.
MedLine Citation:
PMID:  1134     Owner:  NLM     Status:  MEDLINE    
1 The use of radioactive microspheres is described for the measurement of cardiac output in anaesthetized rabbits and its redistribution after the administration of drugs which lower blood pressure. 2 Hydralazine increased peripheral vascular conductance by 123%. The vascular beds in which it had most effect were those of the carcass (mainly muscle) and the kidneys. 3 SK&F 24260, (1,4 dihydro-2, 6-dimethyl-4(2-trifluoremethylpheny)-3,5,-pyridinedicarboxylic acid diethyl ester), had similar vasocilator actions. Its effect in the carcass contributed relatively more to the increase of total peripheral conductance. It also caused a remarkable degree of cerebral vasodilatation. 4 Guanethidine had a relatively small effect on total peripheral conductance and lowered blood pressure mainly by reducing stroke volume and cardiac output.
B M Johnson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  55     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  393-402     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects*
Guanethidine / pharmacology*
Heart Rate / drug effects
Hydralazine / pharmacology*
Hydrocarbons, Fluorinated / pharmacology
Hydrogen-Ion Concentration
Pyridines / pharmacology*
Regional Blood Flow / drug effects
Strontium Radioisotopes
Time Factors
Reg. No./Substance:
0/Hydrocarbons, Fluorinated; 0/Pyridines; 0/Strontium Radioisotopes; 55-65-2/Guanethidine; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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