| The use of quinolones in respiratory tract infections. | |
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MedLine Citation:
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PMID: 3325259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a prospective (and continuing) trial, a total of 271 patients with acute purulent exacerbations of chronic respiratory disease (bacteriologically confirmed) were treated with various new oral quinolones including enoxacin (26), pefloxacin (50), ciprofloxacin (80) and ofloxacin (115). Various therapeutic schedules were employed, with differing drug dosages, frequencies of administration and durations of treatment. All patients were investigated microbiologically during and immediately after treatment and after 7 days of follow-up. The best clinical results were noted after ofloxacin 800 mg once daily for 7 days, which showed excellent gastrointestinal absorption and rapid penetration through to the sputum. Some of the treatment failures with enoxacin and pefloxacin could be ascribed to the development of resistance during treatment, rises in minimal inhibitory concentrations (MICs) being noted with Streptococcus pneumoniae and Pseudomonas aeruginosa. |
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Authors:
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F P Maesen; B I Davies; W H Geraedts; C Baur |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Drugs Volume: 34 Suppl 1 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1987 |
Date Detail:
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Created Date: 1988-03-30 Completed Date: 1988-03-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 74-9 Citation Subset: IM |
Affiliation:
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Department of Respiratory Diseases, De Wever Ziekenhuis, Heerlen. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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adverse effects,
pharmacokinetics,
therapeutic use* Bronchitis / complications Chronic Disease Clinical Trials as Topic Humans Microbial Sensitivity Tests Ofloxacin Oxazines / adverse effects, pharmacokinetics, therapeutic use* Quinolines / therapeutic use* Respiratory Tract Infections / drug therapy*, etiology, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Oxazines; 0/Quinolines; 82419-36-1/Ofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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