Document Detail


The use of prostaglandin E1 and Blalock-Taussig shunts in neonates with cyanotic congenital heart disease.
MedLine Citation:
PMID:  454028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Six unselected neonates with cyanotic congenital heart disease and life-threatening degrees of arterial oxygen desaturation have been managed by a protocol that includes administration of prostaglandin E1 (PGE1) and early Blalock-Taussig shunting. In 5 patients (seven paired observations) partial pressure of arterial oxygen (PaO2) rose from 19 mm Hg to a mean of 32.9 mm Hg within 20 minutes of initiation of PGE1 (0.1 to 0.2 microgram/kg/hr), infused intravenously or through an aortic catheter placed at ductal level or with both methods. The nonresponsive patient was older than the patients showing a positive response (1 month versus 24 to 96 hours). Following catheterization, immediate palliative operation including a Blalock-Taussig shunt was carried out. Although all had a satisfactory PaO2 (mean, 49 mm Hg) postoperatively, the PGE1-nonresponsive patient experienced serious intraoperative bradycardia, hypotension, and acidosis in contrast to the PGE1-responsive group. In this study, the use of PGE1 was not associated with any apparent serious side effects.
Authors:
D A Browdie; W Norberg; R Agnew; B Altenburg; R Ignacio; C Hamilton
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  27     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  508-13     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Drug Evaluation
Ductus Arteriosus / drug effects*
Female
Heart Defects, Congenital / drug therapy,  physiopathology,  surgery*
Heart Septum / surgery
Humans
Infant, Newborn
Infusions, Parenteral
Male
Oxygen / blood
Partial Pressure
Prostaglandins E, Synthetic / administration & dosage,  therapeutic use*
Pulmonary Artery / surgery
Pulmonary Circulation
Subclavian Artery / surgery
Time Factors
Chemical
Reg. No./Substance:
0/Prostaglandins E, Synthetic; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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