| The use of propofol and sevoflurane for surgical anaesthesia in New Zealand White rabbits. | |
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MedLine Citation:
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PMID: 20071409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New Zealand White (NZW) rabbits (n = 34) received intravenous propofol (16 +/- 5 mg/kg) for induction of anaesthesia followed by maintenance with sevoflurane (4.0 +/- 0.5%) in oxygen. All animals underwent ovariohysterectomy. Heart rate, respiratory rate, haemoglobin oxygen saturation, end-tidal carbon dioxide concentration, end-tidal sevoflurane concentration and oesophageal temperature were monitored every 5 min. Time from induction of anaesthesia to tracheal extubation and sternal recumbency were recorded as was the quality of recovery. Direct arterial blood pressure values (mmHg) were recorded every 5 min from 19 rabbits and 22 arterial blood gases analyses were performed (11 postintubation and 11 at the time of recovery). Propofol produced smooth induction of anaesthesia without production of apnoea. Intubation was successfully performed in all but one rabbit in an average of 4 +/- 3 min from the beginning of propofol administration. No ventilatory support was required during the anaesthetic period. Respiratory rate averaged 51 +/- 8 bpm and end-tidal CO(2) (kPa) was 4.0 +/- 0.5 mmHg during anaesthesia. Blood gas values were maintained within normal limits and average mean arterial blood pressure was 73.4 +/- 7.9 mmHg. Time to regain the swallowing reflex following discontinuation of sevoflurane was 2 +/- 1 min and time to sternal recumbency was 8 +/- 0.3 min. No anaesthetic-related mortality occurred and all animals recovered uneventfully. Propofol-sevoflurane anaesthesia produced a good quality of surgical anaesthesia for ovariohysterectomy and stable cardiopulmonary conditions. Propofol-sevoflurane anaesthesia in young healthy NZW rabbits appears to be an effective and practically useful method of anaesthesia. |
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Authors:
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Sandra Allweiler; Matt C Leach; Paul A Flecknell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-13 |
Journal Detail:
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Title: Laboratory animals Volume: 44 ISSN: 1758-1117 ISO Abbreviation: Lab. Anim. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0112725 Medline TA: Lab Anim Country: England |
Other Details:
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Languages: eng Pagination: 113-7 Citation Subset: IM |
Affiliation:
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Colorado State University, Fort Collins, USA. Sandra.Allweiler@ColoState.EDU |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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methods* Anesthetics, Inhalation / pharmacology* Animals Animals, Laboratory / surgery* Blood Pressure / drug effects Body Temperature Carbon Dioxide / blood Female Heart Rate / drug effects Hysterectomy Methyl Ethers / pharmacology* Ovariectomy Propofol / pharmacology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 124-38-9/Carbon Dioxide; 2078-54-8/Propofol; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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