Document Detail

The use of propofol for sedation of critically ill patients undergoing haemodiafiltration.
MedLine Citation:
PMID:  7650257     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the requirement for propofol to provide sedation in critically ill patients in established renal failure during the commencement of haemodiafiltration. DESIGN: Prospective clinical study. SETTING: ICU, University Hospital. PATIENTS: 10 adult patients. All were mechanically ventilated, had acute oliguric renal failure which necessitated continuous veno-venous haemodiafiltration and were receiving a continuous intravenous infusion of propofol for sedation. Sedation was assessed using a scoring system. INTERVENTION: Veno-venous haemodiafiltration. MEASUREMENTS AND RESULTS: Connection of the extracorporeal circuit produced a reduction in plasma propofol concentration in 7 out of 9 patients (one sample misplaced) with subsequent awakening in 3 of these 7 patients. The commencement of haemodiafiltration itself did not significantly influence the requirement for propofol (8 out of 10 patients). CONCLUSION: Haemodiafiltration does not substantially influence the requirement for propofol but the initial introduction of the extracorporeal circuit will reduce plasma concentrations in the majority of patients. This may be due to haemodilution alone or absorption of plasma albumin (with propofol) onto the membrane.
J M Eddleston; B J Pollard; J F Blades; B Doran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  21     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-09-26     Completed Date:  1995-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-7     Citation Subset:  IM    
Department of Anaesthesia, Manchester Royal Infirmary, UK.
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MeSH Terms
Critical Care*
Drug Therapy, Combination
Fentanyl / therapeutic use
Hematologic Tests
Infusions, Intravenous
Kidney Failure, Acute / therapy*
Middle Aged
Propofol / administration & dosage*,  pharmacokinetics
Prospective Studies
Triglycerides / blood
Reg. No./Substance:
0/Triglycerides; 2078-54-8/Propofol; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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