| The use of preintervention and postintervention thallium imaging for assessing the early and late effects of experimental coronary arterial reperfusion in dogs. | |
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MedLine Citation:
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PMID: 6713617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine if thallium-201 imaging of myocardial perfusion can be used as an early predictor of myocardial salvage after reperfusion, 24 adult dogs were subjected to complete occlusion of the left anterior descending coronary artery with release of the snare 2 hr later. Separate doses of thallium (1 mCi) and microspheres were given 15 min before, 5 min after, and 1 hr after release of the snare. Gamma camera images of the heart were obtained after each injection of thallium. Preinjection images were also acquired before the second and third doses and were subtracted from the postinjection images to eliminate the counts due to residual activity from the prior injections. The chest was then closed and the dog allowed to recover. The chest was reopened 48 hr later, final doses of thallium and microspheres were administered, and the heart was imaged. After the dog was killed, the left ventricle was sliced from apex to base, and any infarct was outlined with triphenyltetrazolium (TTC) staining. The slices were then subdivided into pieces of approximately 1 g each and then well counted for microsphere determination of regional myocardial blood flows. Thallium images were interpreted qualitatively and quantitatively. Fifteen dogs with myocardial infarctions, as assessed by TTC staining, all had thallium image defects during coronary arterial occlusion. Thallium scans obtained immediately after reperfusion demonstrated increased anterior wall thallium activity in nine dogs, normal activity in four dogs, and decreased activity in two dogs. In 14 of the 15 dogs, relative thallium activity correlated with the occlusion/normal zone flow ratios.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R D Okada; G M Pohost |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 69 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-06-20 Completed Date: 1984-06-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1153-60 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation Coronary Vessels / radionuclide imaging* Dogs Electrocardiography Heart / radionuclide imaging Hemodynamics Myocardial Infarction / etiology Radioisotopes / diagnostic use* Thallium / diagnostic use* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-21751/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 7440-28-0/Thallium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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