Document Detail

"The use of positive end-expiratory pressure in mechanical ventilation".
MedLine Citation:
PMID:  17368169     Owner:  NLM     Status:  MEDLINE    
An improvement in oxygenation for patients who have acute respiratory failure using PEEP was described close to 40 years ago. Since then, a considerable amount of research has allowed clinicians to use this therapeutic modality in various ways. In patients receiving mechanical ventilation, the term positive end-expiratory pressure (PEEP) refers to pressure in the airway at the end of passive expiration that exceeds atmospheric pressure. The use of PEEP mainly has been reserved to recruit or stabilize lung units and improve oxygenation in patients who have hypoxemic respiratory failure. It has been shown that this helps the respiratory muscles to decrease the work of breathing and the amount of infiltrated-atelectatic tissues. The beneficial effects of the use of PEEP include: the improvement of oxygenation, recruitment of lung units, and improvement of compliance. Other effects can be adverse, like decreasing cardiac output, increased risk of barotrauma, and the interference with assessment of hemodynamic pressures.
Pilar Acosta; Edgardo Santisbon; Joseph Varon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care clinics     Volume:  23     ISSN:  0749-0704     ISO Abbreviation:  Crit Care Clin     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-19     Completed Date:  2007-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507720     Medline TA:  Crit Care Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-61, x     Citation Subset:  IM    
Dorrington Medical Associates, 2219 Dorrington Street, Houston, TX 77030, USA.
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MeSH Terms
Barotrauma / etiology,  prevention & control
Positive-Pressure Respiration / contraindications,  methods,  trends*
Pulmonary Surfactants / metabolism
Respiration, Artificial / adverse effects,  methods,  trends*
Respiratory Distress Syndrome, Adult / etiology,  prevention & control,  therapy*
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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