Document Detail

The use of paraffin-processed tissue and the immunoperoxidase technique in the diagnosis of bullous diseases, lupus erythematosus and vasculitis.
MedLine Citation:
PMID:  7041947     Owner:  NLM     Status:  MEDLINE    
Twenty-two skin biopsies have been split and each half examined either by the immunoperoxidase technique on paraffin-fixed tissue or by both immunoperoxidase (IP) and immunofluorescence (IF) technique on snap-frozen tissue. All twenty-two specimens gave positive results by frozen IF techniques, nineteen out of twenty-two (86%) were positive by frozen IP techniques and sixteen out of twenty-two (72%) were positive by IP on paraffin-fixed material. If retrospective immunopathology is required on a specimen and only paraffin-fixed material is available a positive result may be expected in the majority of cases.
M L Turbitt; R M Mackie; H Young; I Campbell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  106     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-07-19     Completed Date:  1982-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
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MeSH Terms
Dermatitis Herpetiformis / diagnosis
Fluorescent Antibody Technique
Frozen Sections
Immunoenzyme Techniques
Lupus Erythematosus, Discoid / diagnosis*
Lupus Erythematosus, Systemic / diagnosis*
Pemphigoid, Bullous / diagnosis
Pemphigus / diagnosis
Skin Diseases / diagnosis*
Skin Diseases, Vesiculobullous / diagnosis*
Vasculitis / diagnosis*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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