| The use of oral cyclophosphamide with dexamethasone pulse therapy in the treatment of pemphigus vulgaris. | |
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MedLine Citation:
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PMID: 17852639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pemphigus vulgaris (PV) is a severe acquired autoimmune disease. During the past 15 years we used dexamethasone pulse therapy (DP) and oral cyclophosphamide for treatment of our patients with PV. OBJECTIVES: To evaluate the efficacy and side effects of this treatment. Method: The study was a retrospective study. Medical records of 50 known cases of PV, who were treated with dexamethasone pulse therapy and oral cyclophosphamide were evaluated and the patients were re-examined and questioned about their current situations. RESULTS: Thirty-five females and 15 males were treated, out of which 38 finished the study. At the end of study, 21 patients were in remission, 10 patients were in the healing stage, five patients were partially healed and two patients died. The side effects of this method, especially the adverse effects of cyclophosphamide, were less than previously reported. CONCLUSION: Dexamethasone pulse therapy and oral cyclophosphamide is an effective regimen with few side effects in the treatment of mild to moderate PV. |
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Authors:
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Ali Z Momeni; Fariba Iraji; Malih Aminjavaheri; Mahamd Reza Emami; Amir Momeni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of dermatological treatment Volume: 18 ISSN: 0954-6634 ISO Abbreviation: J Dermatolog Treat Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2007-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8918133 Medline TA: J Dermatolog Treat Country: England |
Other Details:
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Languages: eng Pagination: 275-8 Citation Subset: IM |
Affiliation:
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Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran. alizmomeni@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Cyclophosphamide / administration & dosage*, adverse effects Dexamethasone / administration & dosage*, adverse effects Drug Therapy, Combination Female Glucocorticoids / administration & dosage*, adverse effects Humans Immunosuppressive Agents / administration & dosage*, adverse effects Infusions, Intravenous Male Middle Aged Pemphigus / drug therapy*, pathology Retrospective Studies Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunosuppressive Agents; 50-02-2/Dexamethasone; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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