Document Detail


The use of oral cyclophosphamide with dexamethasone pulse therapy in the treatment of pemphigus vulgaris.
MedLine Citation:
PMID:  17852639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pemphigus vulgaris (PV) is a severe acquired autoimmune disease. During the past 15 years we used dexamethasone pulse therapy (DP) and oral cyclophosphamide for treatment of our patients with PV.
OBJECTIVES: To evaluate the efficacy and side effects of this treatment.
METHOD: The study was a retrospective study. Medical records of 50 known cases of PV, who were treated with dexamethasone pulse therapy and oral cyclophosphamide were evaluated and the patients were re-examined and questioned about their current situations.
RESULTS: Thirty-five females and 15 males were treated, out of which 38 finished the study. At the end of study, 21 patients were in remission, 10 patients were in the healing stage, five patients were partially healed and two patients died. The side effects of this method, especially the adverse effects of cyclophosphamide, were less than previously reported.
CONCLUSION: Dexamethasone pulse therapy and oral cyclophosphamide is an effective regimen with few side effects in the treatment of mild to moderate PV.
Authors:
Ali Z Momeni; Fariba Iraji; Malih Aminjavaheri; Mahamd Reza Emami; Amir Momeni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  18     ISSN:  0954-6634     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-05     Completed Date:  2007-11-30     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Cyclophosphamide / administration & dosage*,  adverse effects
Dexamethasone / administration & dosage*,  adverse effects
Drug Therapy, Combination
Female
Glucocorticoids / administration & dosage*,  adverse effects
Humans
Immunosuppressive Agents / administration & dosage*,  adverse effects
Infusions, Intravenous
Male
Middle Aged
Pemphigus / drug therapy*,  pathology
Retrospective Studies
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents; 7S5I7G3JQL/Dexamethasone; 8N3DW7272P/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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