| The use of opioids in fibromyalgia. | |
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MedLine Citation:
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PMID: 21303476 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Fibromyalgia syndrome (FMS) is a chronic disorder of widespread pain with high personal and societal burdens. Although targeted pharmacotherapies have become available in recent years, it remains a challenging condition to treat. Despite no randomized controlled trials addressing the short- or long-term use of opioids in FMS, their use remains prevalent. In this article we discuss the role of opioids and other analgesics in the management of FMS, with particular focus on problems associated with their use. We review aspects of the pathophysiology of FMS and consider how specific factors may contribute to the lack of efficacy of opioids in this condition. Finally, we discuss drugs with combined opioid and anti-opioid action and their roles in FMS. There is insufficient evidence to recommend the routine use of opioids in FMS. As well as having a significant adverse effect profile, their inefficacy may be due to their inability to target the pathophysiologic processes involved in this central sensitization syndrome. |
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Authors:
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Gene-Siew Ngian; Emma K Guymer; Geoffrey O Littlejohn |
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Publication Detail:
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Type: Journal Article Date: 2010-08-23 |
Journal Detail:
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Title: International journal of rheumatic diseases Volume: 14 ISSN: 1756-185X ISO Abbreviation: Int J Rheum Dis Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101474930 Medline TA: Int J Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 6-11 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. International Journal of Rheumatic Diseases © 2010 Asia Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Rheumatology Department, Monash Medical Centre, Melbourne, Victoria, Australia. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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