Document Detail

The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning.
MedLine Citation:
PMID:  8618249     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nausea and vomiting associated with poisoning can complicate treatment and in some cases delay potential antidote administration. Side effect such as lowering the seizure threshold may at times discourage the use of traditional phenothiazine and butyrophenone antiemetics. METHODS: We performed a prospective, single arm, observational study examining the effectiveness of the 5HT3 receptor antagonist ondansetron in the management if nausea and vomiting associated with acetaminophen poisoning. Patients with a history or laboratory evidence of acetaminophen poisoning were eligible for inclusion in the study. Exclusion criteria included age less than 18 or greater than 65, use of other antiemetic therapy within the previous 12 hours, history of preexisting hepatic or hematologic disease, pregnancy, or significant ingestion of other substances. Upon meeting entry criteria, patients were administered 8 mg of intravenous ondansetron. Nausea was graded on a 100 mm scale with number of emetic episodes recorded before and after treatment. RESULTS: Six patients were entered in the study. All patients had nausea and at least one emetic episode prior to ondansetron and prior to administration of N-acetylcysteine. All patients reported relief of nausea after ondansetron. The degree of nausea decreased by an average of 52% at 30 min and 88% at 60 min following ondansetron administration. No significant vital sign changes were recorded in any patient, and there were no complications related to therapy. Three patients were administered N-acetylcysteine, and all tolerated this therapy without vomiting after ondansetron. CONCLUSIONS: Ondansetron appears to be a potentially useful adjunct in the management of nausea and vomiting associated with acetaminophen poisoning.
R F Clark; R Chen; S R Williams; C L Johnson; F Harchelroad
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  34     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1996  
Date Detail:
Created Date:  1996-06-11     Completed Date:  1996-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-7     Citation Subset:  AIM; IM    
University of California; San Diego Regional Poison Center, CA, 92103-8676, USA.
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MeSH Terms
Acetaminophen / poisoning*
Analgesics, Non-Narcotic / poisoning*
Antiemetics / administration & dosage,  adverse effects,  therapeutic use*
Injections, Intravenous
Middle Aged
Nausea / chemically induced,  drug therapy*
Ondansetron / administration & dosage,  adverse effects,  therapeutic use*
Prospective Studies
Vomiting / chemically induced,  drug therapy*
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Antiemetics; 103-90-2/Acetaminophen; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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