| The use of oligoperoxide-coated magnetic nanoparticles to label stem cells. | |
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MedLine Citation:
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PMID: 21830479 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Iron oxide nanoparticles obtained by the coprecipitation of Fe(II) and Fe(III) salts and oxidation were coated with a novel poly(vinyl acetate-co-5-tert-(butylperoxy)-5-methylhex-1-en-3-yne-co-butyl acrylate-co-maleic anhydride) (PVBM) oligomer to ensure colloidal stability. The magnetic nanoparticles were thoroughly characterized by a range of physico-chemical methods, which proved the presence of the coating on the particles. Experiments with rat mesenchymal stem cells (rMSCs) confirmed that PVBM-coated gamma-Fe2O3 nanoparticles were not cytotoxic and that the average efficiency of stem cell labeling was good and comparable to that obtained with commercial agents. The cells labeled with PVBM-coated gamma-Fe2O3 nanoparticles displayed excellent contrast on magnetic resonance (MR) images. Such particles are thus promising for in vivo MR imaging of transplanted cells. Moreover, PVBM offers the possibility of additional modification by grafting compounds that reduce non-specific protein adsorption. |
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Authors:
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Daniela Sponarová; Daniel Horák; Miroslava Trchová; Pavla Jendelová; Vit Herynek; Nataliya Mitina; Alexander Zaichenko; Rostyslav Stoika; Petr Lesný; Eva Syková |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical nanotechnology Volume: 7 ISSN: 1550-7033 ISO Abbreviation: J Biomed Nanotechnol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-08-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230869 Medline TA: J Biomed Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 384-94 Citation Subset: IM |
Affiliation:
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Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 162 06 Prague 6, Czech Republic. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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