Document Detail

The use of olanzapine in the treatment of negative symptoms in Alzheimer's disease.
MedLine Citation:
PMID:  16179669     Owner:  NLM     Status:  MEDLINE    
The authors report findings from an 8-week, open-label trial conducted to evaluate efficacy of olanzapine in treating negative symptoms in Alzheimer's disease (AD). Subjects were AD patients age 50 and older who exhibited untreated neuropsychiatric symptoms. Findings suggest that a therapeutic profile for olanzapine may be appropriate for AD patients experiencing neuropsychiatric problems.
Eric D Rankin; Richard D Layne
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of neuropsychiatry and clinical neurosciences     Volume:  17     ISSN:  0895-0172     ISO Abbreviation:  J Neuropsychiatry Clin Neurosci     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-23     Completed Date:  2005-11-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8911344     Medline TA:  J Neuropsychiatry Clin Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-4     Citation Subset:  IM    
Department of Behavioral Medicine and Psychiatry, West Virginia University, 930 Chestnut Ridge Rd., Morgantown, WV 26505-2854, USA.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / complications
Antipsychotic Agents / therapeutic use*
Behavioral Symptoms / drug therapy*,  etiology
Benzodiazepines / therapeutic use
Drug Administration Schedule
Middle Aged
Neuropsychological Tests / statistics & numerical data
Schizophrenic Psychology*
Treatment Outcome
Reg. No./Substance:
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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