Document Detail


The use of nasal calcitonin in the treatment of post-traumatic algodystrophy.
MedLine Citation:
PMID:  1863827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Calcitonin is widely used in the treatment of algodystrophy but a major disadvantage is the need for its parenteral administration. For this reason, we evaluated the effect of 400 iu of nasal calcitonin in the treatment of post-traumatic algodystrophy in a prospective randomized double-blind study. We found no demonstrable effect on the clinical or skeletal progression of the disorder using sensitive methods of measuring the response to treatment. There was, however, a small but significant hypocalcaemic response in the treatment group despite no change in the other indices of bone turnover. Possible reasons for this lack of clinical and skeletal effect are discussed.
Authors:
D R Bickerstaff; J A Kanis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  30     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-06     Completed Date:  1991-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  291-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Human Metabolism and Clinical Biochemistry, Sheffield.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Bone Density / drug effects
Calcitonin / administration & dosage*,  therapeutic use
Calcium / blood
Fractures, Bone / complications*
Humans
Prospective Studies
Radionuclide Imaging
Radius / injuries*
Reflex Sympathetic Dystrophy / drug therapy*,  etiology,  physiopathology
Chemical
Reg. No./Substance:
7440-70-2/Calcium; 9007-12-9/Calcitonin
Comments/Corrections
Comment In:
Br J Rheumatol. 1992 Aug;31(8):567-9   [PMID:  1643458 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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