| The use of midazolam versus propofol for short-term sedation following coronary artery bypass grafting. | |
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MedLine Citation:
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PMID: 2212256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Midazolam and propofol were compared in an open randomized study for postoperative sedation during 12 h of mechanical ventilation in 40 patients following coronary artery bypass grafting. After an intravenous loading dose of midazolam (50 micrograms.kg-1) or propofol (500 micrograms.kg-1), a titrated continuous infusion was administered of midazolam (mean dose 38.1 micrograms.kg-1.h-1 (SEM 2.6)) or propofol (mean dose 909 micrograms.kg-1.h-1 (SEM 100)) together with a narcotic analgesic infusion. During mechanical ventilation midazolam and propofol produced a similar quality of sedation, but recovery (midazolam 66 min (SEM 16); propofol 24 min (SEM 7)) and weaning from the ventilator (midazolam 243 min (SEM 44); propofol 154 min (SEM 33)) where faster with propofol. In the 2 groups administration of an intravenous loading dose caused a significant decrease in mean arterial pressure but hemodynamic tolerance during maintenance infusion was good. |
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Authors:
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F Snellen; P Lauwers; R Demeyere; G Byttebier; H Van Aken |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Intensive care medicine Volume: 16 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 1990 |
Date Detail:
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Created Date: 1990-11-07 Completed Date: 1990-11-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 312-6 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, University Hospital, Gasthuisberg, Leuven, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Coronary Artery Bypass* Female Hemodynamics / drug effects Humans Infusions, Intravenous Male Midazolam / administration & dosage, pharmacology, therapeutic use* Middle Aged Pain, Postoperative / drug therapy*, physiopathology Propofol / administration & dosage, pharmacology, therapeutic use* Respiration, Artificial* Ventilator Weaning |
| Chemical | |
Reg. No./Substance:
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2078-54-8/Propofol; 59467-70-8/Midazolam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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