Document Detail


The use of midazolam versus propofol for short-term sedation following coronary artery bypass grafting.
MedLine Citation:
PMID:  2212256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Midazolam and propofol were compared in an open randomized study for postoperative sedation during 12 h of mechanical ventilation in 40 patients following coronary artery bypass grafting. After an intravenous loading dose of midazolam (50 micrograms.kg-1) or propofol (500 micrograms.kg-1), a titrated continuous infusion was administered of midazolam (mean dose 38.1 micrograms.kg-1.h-1 (SEM 2.6)) or propofol (mean dose 909 micrograms.kg-1.h-1 (SEM 100)) together with a narcotic analgesic infusion. During mechanical ventilation midazolam and propofol produced a similar quality of sedation, but recovery (midazolam 66 min (SEM 16); propofol 24 min (SEM 7)) and weaning from the ventilator (midazolam 243 min (SEM 44); propofol 154 min (SEM 33)) where faster with propofol. In the 2 groups administration of an intravenous loading dose caused a significant decrease in mean arterial pressure but hemodynamic tolerance during maintenance infusion was good.
Authors:
F Snellen; P Lauwers; R Demeyere; G Byttebier; H Van Aken
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Intensive care medicine     Volume:  16     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1990  
Date Detail:
Created Date:  1990-11-07     Completed Date:  1990-11-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-6     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, University Hospital, Gasthuisberg, Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Coronary Artery Bypass*
Female
Hemodynamics / drug effects
Humans
Infusions, Intravenous
Male
Midazolam / administration & dosage,  pharmacology,  therapeutic use*
Middle Aged
Pain, Postoperative / drug therapy*,  physiopathology
Propofol / administration & dosage,  pharmacology,  therapeutic use*
Respiration, Artificial*
Ventilator Weaning
Chemical
Reg. No./Substance:
2078-54-8/Propofol; 59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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