Document Detail

The use of microbeams to investigate radiation damage in living cells.
MedLine Citation:
PMID:  18710814     Owner:  NLM     Status:  MEDLINE    
The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).
Melvyn Folkard; Kevin M Prise; Geoff Grime; Karen Kirkby; Borivoj Vojnovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-22
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  67     ISSN:  1872-9800     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-03-23     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  England    
Other Details:
Languages:  eng     Pagination:  436-9     Citation Subset:  IM    
Gray Cancer Institute, University of Oxford, PO Box 100, Mount Vernon Hospital, Northwood HA6 2JR, UK.
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MeSH Terms
Bystander Effect / radiation effects*
Cells / radiation effects*
Cytoplasm / radiation effects
DNA / radiation effects
Grant Support
A7047//Cancer Research UK; //Cancer Research UK
Reg. No./Substance:

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