Document Detail


The use of microbeams to investigate radiation damage in living cells.
MedLine Citation:
PMID:  18710814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).
Authors:
Melvyn Folkard; Kevin M Prise; Geoff Grime; Karen Kirkby; Borivoj Vojnovic
Related Documents :
20025604 - Poly(adp-ribose) glycohydrolase deficiency sensitizes mouse es cells to dna damaging ag...
8465254 - Cell kinetic analysis after irradiation in l929- and llc-mk2-cells by a brdu/dna assay.
19157994 - Interaction with dna polymerase eta is required for nuclear accumulation of rev1 and su...
15698664 - Photo-chemically patterned polymer surfaces for controlled pc-12 adhesion and neurite g...
22674854 - Restoration of caveolin-1 expression suppresses growth, membrane-type-4 metalloproteina...
18236634 - Mutations and polymorphisms in mitochondrial dna in head and neck cancer cell lines.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-22
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  67     ISSN:  1872-9800     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-03-23     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  England    
Other Details:
Languages:  eng     Pagination:  436-9     Citation Subset:  IM    
Affiliation:
Gray Cancer Institute, University of Oxford, PO Box 100, Mount Vernon Hospital, Northwood HA6 2JR, UK. folkard@gci.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bystander Effect / radiation effects*
Cells / radiation effects*
Cytoplasm / radiation effects
DNA / radiation effects
Genome
Humans
Grant Support
ID/Acronym/Agency:
A7047//Cancer Research UK; //Cancer Research UK
Chemical
Reg. No./Substance:
9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  NO-donors. Part 17: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compo...
Next Document:  Time-course evaluation and treatment of skin inflammatory immune response after ultraviolet B irradi...