Document Detail

The use of methylprednisolone and hypertonic glucose in the prophylaxis of fat embolism syndrome.
MedLine Citation:
PMID:  509829     Owner:  NLM     Status:  MEDLINE    
In a prospective randomized trial of prophylactic therapy in fat embolism syndrome (FES) 64 patients with femoral and/or tibial shaft fractures uncomplicated by other significant injuries were treated with hypertonic glucose (A), methylprednisolone (B), and placebo (C). Clinical findings and several laboratory parameters were used to establish the diagnosis. Two of the 23 patients in the placebo group (C), 3 of the 21 patients in the hypertonic dextrose (A) group and none of the 20 patients in the methylprednisolone (B) group developed clinical fat embolism syndrome. All patients with fat embolism syndrome were hypoxemic (pO2 less than 65 mm Hg) and exhibited central nervous system symptoms. Four out of 5 were hypocalcemic and 3 patients had thrombocytopenia. There was a high incidence of subclinical hypoxemia or subclinical fat embolism syndrome (29% in A Group, 15% in B Group and 39% in C Group). A comparison between groups of the mean pO2 for each patient demonstrated a statistically significant difference between the methylprednisolone group and the control group (p less than 0.025) as was the comparison of proportions of pO2 less than 70 mm Hg (methylprednisolone versus control p less than 0.01, glucose versus control p less than 0.03). Methylprednisolone given prophylactically may reduce the incidence of fat embolism syndrome and can reduce the degree of hypoxemia associated with long bone fractures of the lower extremmity.
J J Stoltenberg; R B Gustilo
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1980-02-15     Completed Date:  1980-02-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-21     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Cell Count
Blood Platelets
Embolism, Fat / etiology,  prevention & control*
Evaluation Studies as Topic
Femoral Fractures / complications
Glucose / administration & dosage*
Hypertonic Solutions
Methylprednisolone / therapeutic use*
Oxygen / blood
Radius Fractures / complications
Tibial Fractures / complications
Reg. No./Substance:
0/Hypertonic Solutions; 50-99-7/Glucose; 7782-44-7/Oxygen; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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