| The use of the mechanical fragility test in evaluating sublethal RBC injury during storage. | |
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MedLine Citation:
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PMID: 20673245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The mechanical fragility index (MFI) is an in vitro measurement of the extent of RBC sublethal injury. Sublethal injury might constitute a component of the RBC storage lesion, thus the MFI was determined serially during routine RBC storage. METHODS: Leucoreduced AS-5- and SAGM-preserved RBCs were stored under routine blood bank conditions. The mechanical fragility (MF) of each unit was serially measured during storage. RESULTS: For both AS-5 and SAGM units, male and female RBCs demonstrated statistically significant increases in the MFI during storage. The MFI was significantly lower in AS-5 units compared to SAGM units throughout storage. Female RBCs had significantly lower MFI vs. male RBCs in both AS-5 and SAGM units at all times. No significant differences in MFI were observed between ABO groups for both genders for AS-5 RBCs. CONCLUSIONS: The MF of RBCs increases during storage. Both gender and preservation solution influenced the MFI; however, the male:female MFI ratios were similar at all time-points and remained stable, suggesting that gender-based biological differences exist independent of storage solution. The MF could be a useful test for evaluating the effect of novel interventions intended to mitigate the susceptibility of RBCs to sublethal injury during storage. |
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Authors:
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J S Raval; J H Waters; A Seltsam; E A Scharberg; E Richter; A R Daly; M V Kameneva; M H Yazer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vox sanguinis Volume: 99 ISSN: 1423-0410 ISO Abbreviation: Vox Sang. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413606 Medline TA: Vox Sang Country: England |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s). Vox Sanguinis © 2010 International Society of Blood Transfusion. |
Affiliation:
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Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System* Adult Blood Banks* Cell Survival Erythrocytes / cytology* Female Hemolysis* Humans Male Middle Aged Preservation, Biological / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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