Document Detail

The use of levomepromazine in Hyperemesis Gravidarum resistant to drug therapy--a case series.
MedLine Citation:
PMID:  16199349     Owner:  NLM     Status:  MEDLINE    
Hyperemesis Gravidarum (HG) is a potentially serious complication of early pregnancy, which may rarely be severe enough to warrant termination of pregnancy. HG requires prompt treatment with intravenous fluids, thiamine supplementation and appropriate anti-emetic therapy. Anti-histamines such as promethazine are favoured as first-line agents, with prochlorperazine being used as a second-line drug. However, there is no clear data as to the most appropriate drug if these are ineffective. A case series of six women who presented with HG resistant to drug treatment is described. In these cases, levomepromazine 6.25mg tds was used to control HG. Five pregnancies progressed leading to live born infants with no evidence of congenital anomaly. One pregnancy resulted in an intra-uterine death with no external or ultrasound evidence of congenital anomaly. The role of phenothiazines in the pharmacological management of HG is discussed.
Alexander E P Heazell; Nigel Langford; Jatinder K Judge; Martin A Heazell; Gabrielle P Downey
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-04-15
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  20     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2005-10-03     Completed Date:  2006-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  569-72     Citation Subset:  IM    
Maternal and Fetal Health Research Centre, Division of Human Development, University of Manchester, St. Mary's Hospital, Whitworth Park, Manchester M13 0JH, UK.
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MeSH Terms
Dopamine Antagonists / administration & dosage,  therapeutic use*
Hyperemesis Gravidarum / drug therapy*
Methotrimeprazine / administration & dosage,  therapeutic use*
Pregnancy Outcome
Prenatal Care
Reg. No./Substance:
0/Dopamine Antagonists; 60-99-1/Methotrimeprazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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