| The use of isoflurane anaesthesia in studies of carnitine metabolism in the laboratory rat. | |
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MedLine Citation:
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PMID: 8938626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the effect of isoflurane anaesthesia in the rat prior to decapitation on metabolites of interest in studies of carnitine metabolism. Male and female fed and starved rats were allocated to either the decapitation group, or to the anaesthesia-decapitation group. Six animals were allocated to each treatment. Within each gender and within feeding status, there were no significant effects of isoflurane anaesthesia with regard to plasma and liver carnitine, plasma beta-hydroxybutyrate and free fatty acids, or liver free fatty acids, triglycerides, free CoA, and acetyl CoA (P > 0.05). It was concluded that isoflurane anaesthesia can be used in studies of carnitine metabolism where the rat is used as a model. |
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Authors:
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A T Davis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Laboratory animals Volume: 30 ISSN: 0023-6772 ISO Abbreviation: Lab. Anim. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1997-03-10 Completed Date: 1997-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0112725 Medline TA: Lab Anim Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 377-82 Citation Subset: IM |
Affiliation:
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Department of Surgery, Michigan State University, Grand Rapids 49503, USA. davisa@pilot.msu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid Acetyl Coenzyme A / metabolism Anesthesia* Animals Carnitine / blood, metabolism* Coenzyme A / metabolism Fatty Acids, Nonesterified / blood, metabolism Female Hydroxybutyrates / blood Isoflurane* Liver / metabolism Male Rats Rats, Sprague-Dawley Triglycerides / metabolism Weaning |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 0/Triglycerides; 26675-46-7/Isoflurane; 300-85-6/3-Hydroxybutyric Acid; 541-15-1/Carnitine; 72-89-9/Acetyl Coenzyme A; 85-61-0/Coenzyme A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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