| The use of intravitreal thrombin to control hemorrhage during vitrectomy. | |
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MedLine Citation:
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PMID: 3703495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of intravitreal bovine thrombin to control intraoperative bleeding was investigated by a prospective double blind study of 28 consecutive patients with vascularized preretinal membranes undergoing vitrectomy for diabetic retinopathy. Addition of thrombin (100 units/ml) to the vitrectomy infusate was associated with a significantly reduced intraocular bleeding time after cutting vascularized membranes. The mean bleeding time without thrombin was 111.5 seconds, compared to 12.3 seconds with intravitreal thrombin (P less than 0.0001). Patients receiving thrombin had less overall bleeding during surgery and less vitreous hemorrhage on the second postoperative day. Intravitreal bovine thrombin was associated with increased postoperative intraocular inflammation in 20% of patients receiving thrombin. This inflammation could be controlled by use of frequent topical steroids. |
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Authors:
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J T Thompson; B M Glaser; R G Michels; S de Bustros |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ophthalmology Volume: 93 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-06-16 Completed Date: 1986-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 279-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Diabetic Retinopathy / complications Double-Blind Method Eye Diseases / prevention & control* Hemorrhage / prevention & control* Humans Injections Intraoperative Period Random Allocation Retinal Detachment / etiology, surgery Retinal Diseases / etiology, surgery Thrombin / administration & dosage*, therapeutic use Vitrectomy* Vitreous Body |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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