Document Detail

The use of interferon gamma release assays in the diagnosis of active tuberculosis.
MedLine Citation:
PMID:  22567275     Owner:  NLM     Status:  In-Data-Review    
Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium tuberculosis infection. They cannot differentiate between latent and active infections. The cutoff suggested by the manufacturer is 0.35 IU/mL for latent tuberculosis. As IGRA tests were recently approved for the differential diagnosis of active tuberculosis, we assessed the diagnostic accuracy of the latest generation IGRA for detection of active tuberculosis in a low-incidence area in Germany. Our consecutive case series includes 61 HIV negative, Mycobacterium tuberculosis culture positive patients, as well as 234 control patients. The retrospective analysis was performed over a period of two years. In 11/61 patients with active tuberculosis (18.0%) the test result was <0.35 IU/mL, resulting in a sensitivity of 0.82. We recommend establishing a new cut-off value for the differential diagnosis of active tuberculosis assessed by prospective clinical studies and in various regions with high and low prevalence of tuberculosis.
Silvan M Vesenbeckh; Nicolas Schönfeld; Harald Mauch; Thorsten Bergmann; Sonja Wagner; Torsten T Bauer; Holger Rüssmann
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Publication Detail:
Type:  Journal Article     Date:  2012-01-22
Journal Detail:
Title:  Tuberculosis research and treatment     Volume:  2012     ISSN:  2090-1518     ISO Abbreviation:  Tuberc Res Treat     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576351     Medline TA:  Tuberc Res Treat     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  768723     Citation Subset:  -    
Department of Pneumology, Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, 14165 Berlin, Germany.
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