Document Detail


The use of intensity-modulated radiation therapy photon beams for improving the dose uniformity of electron beams shaped with MLC.
MedLine Citation:
PMID:  21925867     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Electrons are ideal for treating shallow tumors and sparing adjacent normal tissue. Conventionally, electron beams are collimated by cut-outs that are time-consuming to make and difficult to adapt to tumor shape throughout the course of treatment. We propose that electron cut-outs can be replaced using photon multileaf collimator (MLC). Two major problems of this approach are that the scattering of electrons causes penumbra widening because of a large air gap, and available commercial treatment planning systems (TPSs) do not support MLC-collimated electron beams. In this study, these difficulties were overcome by (1) modeling electron beams collimated by photon MLC for a commercial TPS, and (2) developing a technique to reduce electron beam penumbra by adding low-energy intensity-modulated radiation therapy (IMRT) photons (4 MV). We used blocks to simulate MLC shielding in the TPS. Inverse planning was used to optimize boost photon beams. This technique was applied to a parotid and a central nervous system (CNS) clinical case. Combined photon and electron plans were compared with conventional plans and verified using ion chamber, film, and a 2D diode array. Our studies showed that the beam penumbra for mixed beams with 90 cm source to surface distance (SSD) is comparable with electron applicators and cut-outs at 100 cm SSD. Our mixed-beam technique yielded more uniform dose to the planning target volume and lower doses to various organs at risk for both parotid and CNS clinical cases. The plans were verified with measurements, with more than 95% points passing the gamma criteria of 5% in dose difference and 5 mm for distance to agreement. In conclusion, the study has demonstrated the feasibility and potential advantage of using photon MLC to collimate electron beams with boost photon IMRT fields.
Authors:
Homeira Mosalaei; Scott Karnas; Sheel Shah; Sharon Van Doodewaard; Tim Foster; Jeff Chen
Related Documents :
12784647 - Formate-forming fungal catabolic pathway to supply electrons to nitrate respiration.
24357367 - Electron microscopy of microtubule cytoskeleton assembly in vitro.
23834497 - Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered al...
12889607 - Anaerobic desulphurisation of thiophenes by mixed microbial communities from oilfields.
21878327 - Recent advances in cytochrome bc(1): inter monomer electronic communication?
25296027 - Investigation of gold nanoparticle radiosensitization mechanisms using a free radical s...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-16
Journal Detail:
Title:  Medical dosimetry : official journal of the American Association of Medical Dosimetrists     Volume:  -     ISSN:  1873-4022     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908862     Medline TA:  Med Dosim     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.
Affiliation:
London Regional Cancer Program, London Health Science Centre, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adaptive planning using megavoltage fan-beam CT for radiation therapy with testicular shielding.
Next Document:  Minimally- and non-invasive assessment of maternal cardiac output: go with the flow!