Document Detail


Cocaine/polydrug use in pregnancy: two-year follow-up.
MedLine Citation:
PMID:  1370867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The impact of cocaine on pregnancy and neonatal outcome has been well documented over the past few years, but little information regarding long-term outcome of the passively exposed infants has been available. In the present study, the 2-year growth and developmental outcome for three groups of infants is presented: group 1 infants exposed to cocaine and usually marijuana and/or alcohol (n = 106), group 2 infants exposed to marijuana and/or alcohol but no cocaine (n = 45), and group 3 infants exposed to no drugs during pregnancy. All three groups were similar in racial and demographic characteristics and received prenatal care through a comprehensive drug treatment and follow-up program for addicted pregnant women and their infants. The group 1 infants demonstrated significant decreases in birth weight, length, and head circumference, but by a year of age had caught up in mean length and weight compared with control infants. The group 2 infants exhibited only decreased head circumference at birth. Head size in the two drug-exposed groups remained significantly smaller than in control infants through 2 years of age. On the Bayley Scales of Infant Development, mean developmental scores of the two groups of drug-exposed infants did not vary significantly from the control group, although an increased proportion of group 1 and 2 infants scored greater than two standard deviations below the standardized mean score on both the Mental Developmental Index and the Psychomotor Developmental Index compared with the control infants. Cocaine exposure was found to be the single best predictor of head circumference.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
I J Chasnoff; D R Griffith; C Freier; J Murray
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  89     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-02-28     Completed Date:  1992-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Northwestern University Medical School, Chicago, IL.
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Cocaine*
Cohort Studies
Developmental Disabilities / epidemiology*
Female
Follow-Up Studies
Head / anatomy & histology
Humans
Infant
Infant, Newborn
Pregnancy
Pregnancy Complications*
Prenatal Exposure Delayed Effects*
Risk Factors
Substance-Related Disorders / complications*
Time Factors
Grant Support
ID/Acronym/Agency:
DA04103/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine
Comments/Corrections
Comment In:
Pediatrics. 1992 Feb;89(2):337-9   [PMID:  1370868 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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